Europe - Europa League
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by Sridhar | in Europa League Predictions
With their season on the line, Manchester United face a battle at home against Lyon in the UEFA Europa League second leg of the quarter-finals. The teams are locked 2-2 from the first leg, and this match on Thursday at Old Trafford between the Red Devils and Les Gones comes with our prediction of both teams scoring goals. The winner of this two-legged tie will face the winner of Rangers vs Athletic Bilbao in the semi-finals.
Qualifying for Europe next season through the league is out of United’s reach, which puts all their focus on this competition. The hosts are the 2017 winners, and repeating that feat is the only way Ruben Amorim can save the season. It could have been a different case here if Andre Onana’s blunder in the first leg at 2-1 had cost them a win.
Lyon will feel they got a new wind of life after that goal and are likely to go all out for progression here. Up for grabs is a chance to make it to just the fifth UEFA semi-final in the history of the club. Will that be incentive enough for the French visitors to surprise United? Read further for our predictions.
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The Best Betting Odds for Manchester United v Lyon Match
Bookmaker | 1 | X | 2 | Bonus up to |
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1.7 | 4.1 | 4.5 |
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1.73 | 3.75 | 4.33 |
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1.7 | 4 | 4.5 |
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1.68 | 3.9 | 4.3 |
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1.77 | 4.17 | 4.74 |
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What is the prediction for the football match between Manchester United and Lyon?
Our prediction for the Manchester United vs Lyon match is: both teams to score.
Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 17/04/2025 between Manchester United and Lyon in Europa League :
- The Sportytrader ⭐ algorithm estimates a probability of 35.72% for a win of Manchester United against Lyon with odds of 1.77 at 1xbet.
- The probability according to Sportytrader ⭐ for a draw between Manchester United vs Lyon is 33.35% with odds of 4.17 at 1xbet.
- Our prediction model gives a 30.93% chance ⭐ for a win of Lyon vs Manchester United with odds of 4.8 at Unibet.
Manchester United vs Lyon Form
Manchester United and Lyon Last Matches

2/6 (33%)
2/6 (33%)
2/6 (33%)
Average stats (Last 6 matchs)
13 Apr 2025 - Premier League
10 Apr 2025 - Europa League
6 Apr 2025 - Premier League
1 Apr 2025 - Premier League
16 Mar 2025 - Premier League
13 Mar 2025 - Europa League
3/6 (50%)
3/6 (50%)
0/6 (0%)
Average stats (Last 6 matchs)
6 Apr 2025 - Premier League
13 Mar 2025 - Europa League
9 Mar 2025 - Premier League
2 Mar 2025 - FA Cup
26 Feb 2025 - Premier League
7 Feb 2025 - FA Cup
1/6 (17%)
3/6 (50%)
2/6 (33%)
Average stats (Last 6 matchs)
13 Apr 2025 - Premier League
10 Apr 2025 - Europa League
1 Apr 2025 - Premier League
16 Mar 2025 - Premier League
6 Mar 2025 - Europa League
22 Feb 2025 - Premier League

4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
13 Apr 2025 - Ligue 1
10 Apr 2025 - Europa League
5 Apr 2025 - Ligue 1
28 Mar 2025 - Ligue 1
16 Mar 2025 - Ligue 1
13 Mar 2025 - Europa League
4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
10 Apr 2025 - Europa League
5 Apr 2025 - Ligue 1
16 Mar 2025 - Ligue 1
13 Mar 2025 - Europa League
2 Mar 2025 - Ligue 1
23 Feb 2025 - Ligue 1
4/6 (67%)
0/6 (0%)
2/6 (33%)
Average stats (Last 6 matchs)
13 Apr 2025 - Ligue 1
28 Mar 2025 - Ligue 1
9 Mar 2025 - Ligue 1
6 Mar 2025 - Europa League
16 Feb 2025 - Ligue 1
2 Feb 2025 - Ligue 1
Manchester United vs Lyon Stats: Head to Head (H2H)
10 Apr 2025 - Europa League
Manchester United - Lyon: Form Analysis
After a 2-2 draw in the first leg where Andre Onana’s last blunder cost them, United rotated heavily at the weekend in a 4-1 loss at Newcastle United in the Premier League. That result left the Red Devils winless in four matches, drawing and losing two each.
With their league position (14th) keeping them 16 points adrift of European qualification spots, it is evident United’s season is hanging on progressing in this tournament. Winning the Europa League is not just winning silverware but also qualifying for Europe next season! The challenge is to improve their form at Old Trafford, having won just one of their last four home matches in all competitions.
United won their last four home matches in the Europa League.
That’s a huge boost to the struggling Red Devils, but Lyon won’t be an easy pushover. The French visitors were 3-1 winners at the weekend at Auxerre, making it seven wins from their last nine competitive matches, losing only once.
They are still in the reckoning to finish in the top three in Ligue 1 and thereby qualify for the Champions League through the league. That takes some pressure away from their Europa League progression, but a chance to make it to just a fifth UEFA semi-final in their history is something they don’t want to lose!
Lyon’s away form gives them further hope, as the visitors are unbeaten in their last five Europa League trips, winning three and drawing two.
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Manchester United vs Lyon last Lineups
Formation : 3 - 4 - 2 - 1
Formation : 4 - 2 - 3 - 1
Missing players

J. Evans
L. Martinez
MidfielderA. Diallo

E. Nuamah
P. Akouokou
ForwardM. Fofana
Manchester United & Lyon Squad Analysis
The already lengthy absence list of United got longer, as forward Joshua Zirkzee subbed off in the weekend’s match against Newcastle United. He scored United’s second goal in the first leg before Lyon found a late equaliser.
The Dutchman joins the likes of Matthijs de Ligt, Tobias Collyer, and Amad on the injury list. Even Lisandro Martinez and Johnny Evans are out for the season for the Red Devils.
That puts Rasmus Hojlund as United’s option up front in the 3-4-2-1 formation for Amorim’s side. The Dane has five goals and two assists in the Europa League and could fancy his chances here. The real star could be Bruno Fernandes, who has four goals and three assists in this year’s competition.
Andre Onana will be under scrutiny after the first-leg.
The Cameroonian has been volatile under the sticks and has just one clean sheet in nine Europa League matches this season, conceding 12 goals in the process!
Those numbers must give Lyon hope of progressing in this competition, as they target a semi-final appearance. Their goals in the first leg were scored by Thiago Almada and Rayan Cherki. The second of those goals was assisted by Georges Mikautadze, who also scored and assisted once each against Auxerre.
Cherki and Mikautadze are expected to be on the wings in their 4-2-3-1 with Alexandre Lacazette likely to lead the line. It could be an interesting game for the former Red Devils’ midfielder Nemanja Matic, who had a war of words with Onana.
Most goals and assists






Manchester United and Lyon Stats in Europa League


Manchester United - Lyon Key Points
- United have failed to keep a clean sheet in 12 of their last 13 home matches in all competitions.
- Eight of United’s last 11 matches in all competitions have seen goals from both teams.
- Four of United’s last five home matches in the Europa League have seen both teams find the net.
- In nine of the last 11 matches involving Lyon in all competitions, both teams scored goals.
- Lyon failed to keep a clean sheet in four of their last five away matches in the Europa League, scoring in each of those fixtures.
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Our Manchester United vs Lyon Prediction
An incredible first leg in France keeps the tie wide open as both Manchester United and Lyon can harbour hopes of progressing to the semis of the UEFA Europa League. Undoubtedly, there’s more pressure on United to deliver, as their season is practically hinging on winning this tournament, as qualifying for Europe through the league is not possible. Lyon have won seven of their last nine competitive matches and won’t be an easy pushover. This could be another classic waiting for us, and our Manchester United vs Lyon prediction is both teams to score.
Manchester United vs Lyon - Other Interesting Predictions
Bruno Fernandes to score anytime.
To say that Bruno Fernandes is United’s talisman is just understating the obvious. The United captain has been their best player all through the season, and with such a key game like this, the home fans will place their hopes on Bruno. What plays to his advantage is that his last seven goals in this competition have all come at this venue. Another scoring performance from him will boost their chances of qualifying for the semis and keep their season alive. Back Bruno to score.
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Manchester United vs Lyon match : Frequently asked questions
The Manchester United v Lyon UEFA Europa League match will be shown live on TNT Sports in the UK and on Canal+ in France.
You can also follow the game through our live scores. Check out our UEFA Europa League Livescore page!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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