Stefanos Tsitsipas vs Lorenzo Musetti Prediction & Picks - ATP Mutua Madrid Open

ATP - ATP Mutua Madrid Open

ATP 18 Greece
Stefanos Tsitsipas
4/28/25 14:00
ATP 11 Italy
Lorenzo Musetti

Prediction:

 

Stefanos Tsitsipas will win 2-1

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 by Lou Aguila in ATP Mutua Madrid Open Picks

Stefanos Tsitsipas of Greece and Lorenzo Musetti of Italy will contest for a spot in the round-of-16 at the 2025 Mutua Madrid Masters on Monday.

Tsitsipas is inching closer to the championship rounds of the 2025 Madrid Open after outgunning Jan-Lennard Struff of Germany 3-6 6-4 6-3. Tsitsipas, a quarterfinalist at Monte Carlo and Barcelona Open, refused to crash out early in the ATP 1000 level event, showing incredible resilience to come back from a set down and beat his German foe in three sets.

Musetti won his first match since losing to Carlos Alcaraz 7-6(3) 6-2 in the final of the 2025 Monte Carlo Masters over a couple of weeks ago. The Italian overcame a shaky start against Tomas Martin Etcheverry of Argentina by converting on his serves while gaining three pivotal service breaks to carve out a 7-6(3) 6-2 win in the second round.

Stefanos Tsitsipas vs Lorenzo Musetti Form

Stefanos Tsitsipas and Lorenzo Musetti Latest Matches

Stefanos Tsitsipas Latest matches
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 26, 2025 - ATP Mutua Madrid Open

Stefanos Tsitsipas
2 :  1
Jan-Lennard Struff

Apr 18, 2025 - ATP Barcelona

Stefanos Tsitsipas
abort
Arthur Fils

Apr 16, 2025 - ATP Barcelona

Stefanos Tsitsipas
2 :  0
Sebastian Korda

Apr 15, 2025 - ATP Barcelona

Stefanos Tsitsipas
2 :  0
Reilly Opelka

Apr 11, 2025 - ATP Monte Carlo Masters

Lorenzo Musetti
2 :  1
Stefanos Tsitsipas

Apr 10, 2025 - ATP Monte Carlo Masters

Nuno Borges
0 :  2
Stefanos Tsitsipas
Lorenzo Musetti Latest matches
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 26, 2025 - ATP Mutua Madrid Open

Tomas Martin Etcheverry
0 :  2
Lorenzo Musetti

Apr 13, 2025 - ATP Monte Carlo Masters

Lorenzo Musetti
1 :  2
Carlos Alcaraz

Apr 12, 2025 - ATP Monte Carlo Masters

Lorenzo Musetti
2 :  1
Alex De Minaur

Apr 11, 2025 - ATP Monte Carlo Masters

Lorenzo Musetti
2 :  1
Stefanos Tsitsipas

Apr 10, 2025 - ATP Monte Carlo Masters

Matteo Berrettini
0 :  2
Lorenzo Musetti

Apr 9, 2025 - ATP Monte Carlo Masters

Jiri Lehecka
1 :  2
Lorenzo Musetti

Stefanos Tsitsipas against Lorenzo Musetti : Head to Head (H2H)

Stefanos Tsitsipas

83 %

Lorenzo Musetti

17 %

Apr 11, 2025 - ATP Monte Carlo Masters

Lorenzo Musetti
2 :  1
Stefanos Tsitsipas

May 16, 2023 - ATP Italian Open

Stefanos Tsitsipas
2 :  0
Lorenzo Musetti

Apr 22, 2023 - ATP Barcelona

Lorenzo Musetti
1 :  2
Stefanos Tsitsipas

May 24, 2022 - ATP French Open

Lorenzo Musetti
2 :  3
Stefanos Tsitsipas

May 22, 2021 - ATP Lyon Open

Lorenzo Musetti
1 :  2
Stefanos Tsitsipas

Mar 20, 2021 - ATP Acapulco Open

Stefanos Tsitsipas
2 :  0
Lorenzo Musetti
Compare Stefanos Tsitsipas and Lorenzo Musetti with our comparison tool.

Stefanos Tsitsipas - Lorenzo Musetti Key Points

  1. Stefanos Tsitsipas defeated Jan-Lennard Struff 3-6 6-4 6-3 in the second round of the 2025 Madrid Open.
  2. Stefanos Tsitsipas is 5-1 head-to-head vs. Lorenzo Musetti
  3. Lorenzo Musetti defeated Tomas Martin Etcheverry 7-6(3) 6-2 in the second round of the 2025 Madrid Open.
  4. Lorenzo Musetti is the 2025 Monte Carlo Masters runner-up.

Our Stefanos Tsitsipas vs Lorenzo Musetti Prediction

Fearless Forecast: Stefanos Tsitsipas overwhelms Lorenzo Musetti to win in straight sets.

I still think Lorenzo Musetti is not yet 100 percent healthy after injuring his right thigh in the final vs. Carlos Alcaraz in Monaco. Although the two-set win over Tomas Martin Etcheverry is impressive, Musetti has to raise the level of his play when he dukes it out with Tsitsipas, a finalist in this tournament in 2019. Tsitsipas is coming into the match prepared for a potential three-setter after overcoming a serious upset bid from Struff in the second round. I won’t be shocked if this match needs multiple tiebreakers to determine the winner, but I think Tsitsipas is hungrier and healthier than the Italian ahead of their 7th career meeting. Our betting prediction for Lorenzo Musetti vs. Stefanos Tsitsipas: Stefanos Tsitsipas will win 2-1.

Prediction:

 

Stefanos Tsitsipas will win 2-1

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Stefanos Tsitsipas vs Lorenzo Musetti Picks