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St. Louis Cardinals vs Atlanta Braves Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
4/22/25 18:15
Atlanta Braves

Prediction:

 

St. Louis Cardinals win both halves

+116
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 by Erik Gibbs | in MLB Picks

The Atlanta Braves return home riding a wave of momentum after a weekend sweep of the Minnesota Twins, hoping to carry that success into a fresh three-game series against the St. Louis Cardinals starting Monday night. After an uneven start to the 2025 campaign, Atlanta appears to be finding its rhythm, having won three straight games and six of their last ten. Still, their next challenge comes in the form of a capable Cardinals team led by a rejuvenated Erick Fedde on the mound.

Fedde, who revitalized his career with a stint in the KBO before returning to Major League Baseball in 2023, has become a dependable piece in the Cardinals’ rotation. Over his last 35 starts since rejoining MLB, Fedde owns an impressive 3.31 ERA and a 1.16 WHIP.

While not known for racking up strikeouts, his ability to keep hitters off balance and work efficiently through lineups has been vital for St. Louis. So far this season, he’s delivered quality outings in three of his four starts, despite some early control issues.

St. Louis Cardinals vs Atlanta Braves Form

Table

Teams % P W L
22
Atlanta Braves
Atlanta Braves
0.409 22 9 13
25
St. Louis Cardinals
St. Louis Cardinals
0.391 23 9 14

St. Louis Cardinals and Atlanta Braves Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 21, 2025 - MLB

St. Louis Cardinals
6 :  7
Atlanta Braves

Apr 20, 2025 - MLB

St. Louis Cardinals
4 :  7
New York Mets

Apr 19, 2025 - MLB

St. Louis Cardinals
0 :  3
New York Mets

Apr 18, 2025 - MLB

St. Louis Cardinals
4 :  5
New York Mets

Apr 17, 2025 - MLB

St. Louis Cardinals
1 :  4
New York Mets

Apr 16, 2025 - MLB

Houston Astros
1 :  4
St. Louis Cardinals
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 16, 2025 - MLB

Houston Astros
1 :  4
St. Louis Cardinals

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 13, 2025 - MLB

Philadelphia Phillies
0 :  7
St. Louis Cardinals

Apr 12, 2025 - MLB

Philadelphia Phillies
4 :  1
St. Louis Cardinals

Apr 11, 2025 - MLB

Philadelphia Phillies
0 :  2
St. Louis Cardinals
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 21, 2025 - MLB

St. Louis Cardinals
6 :  7
Atlanta Braves

Apr 20, 2025 - MLB

St. Louis Cardinals
4 :  7
New York Mets

Apr 19, 2025 - MLB

St. Louis Cardinals
0 :  3
New York Mets

Apr 18, 2025 - MLB

St. Louis Cardinals
4 :  5
New York Mets

Apr 17, 2025 - MLB

St. Louis Cardinals
1 :  4
New York Mets

Apr 9, 2025 - MLB

St. Louis Cardinals
1 :  2
Pittsburgh Pirates
Atlanta Braves
Atlanta Braves Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 21, 2025 - MLB

St. Louis Cardinals
6 :  7
Atlanta Braves

Apr 20, 2025 - MLB

Minnesota Twins
2 :  6
Atlanta Braves

Apr 19, 2025 - MLB

Minnesota Twins
3 :  4
Atlanta Braves

Apr 18, 2025 - MLB

Minnesota Twins
4 :  6
Atlanta Braves

Apr 16, 2025 - MLB

Atlanta Braves
1 :  3
Toronto Blue Jays

Apr 15, 2025 - MLB

Atlanta Braves
3 :  6
Toronto Blue Jays
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 21, 2025 - MLB

St. Louis Cardinals
6 :  7
Atlanta Braves

Apr 20, 2025 - MLB

Minnesota Twins
2 :  6
Atlanta Braves

Apr 19, 2025 - MLB

Minnesota Twins
3 :  4
Atlanta Braves

Apr 18, 2025 - MLB

Minnesota Twins
4 :  6
Atlanta Braves

Apr 10, 2025 - MLB

Philadelphia Phillies
2 :  4
Atlanta Braves

Apr 9, 2025 - MLB

Philadelphia Phillies
4 :  3
Atlanta Braves
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 16, 2025 - MLB

Atlanta Braves
1 :  3
Toronto Blue Jays

Apr 15, 2025 - MLB

Atlanta Braves
3 :  6
Toronto Blue Jays

Apr 14, 2025 - MLB

Atlanta Braves
8 :  4
Toronto Blue Jays

Apr 13, 2025 - MLB

Atlanta Braves
3 :  8
Tampa Bay Rays

Apr 12, 2025 - MLB

Atlanta Braves
5 :  4
Tampa Bay Rays

Apr 11, 2025 - MLB

Atlanta Braves
3 :  6
Tampa Bay Rays

St. Louis Cardinals against Atlanta Braves : Head to Head (H2H)

St. Louis Cardinals

50 %

Atlanta Braves

50 %

Apr 21, 2025 - MLB

St. Louis Cardinals
6 :  7
Atlanta Braves

Jul 21, 2024 - MLB

St. Louis Cardinals
6 :  2
Atlanta Braves

Jul 20, 2024 - MLB

St. Louis Cardinals
9 :  5
Atlanta Braves

Jul 20, 2024 - MLB

St. Louis Cardinals
2 :  3
Atlanta Braves

Jun 26, 2024 - MLB

Atlanta Braves
1 :  4
St. Louis Cardinals

Jun 26, 2024 - MLB

Atlanta Braves
6 :  2
St. Louis Cardinals

St. Louis Cardinals - Atlanta Braves Key Points

  1. The Cardinals are 11-12-0 ATS this season
  2. The Braves are 9-12 ATS this season
  3. The Cardinals are 6-4 SU vs. the Braves in their last 10 games
  4. The Braves are 3-5 in their last 8 games vs. the Cardinals when favorites

Our St. Louis Cardinals vs Atlanta Braves Prediction

The Braves will likely have their hands full against Fedde, especially with their current pitching situation in flux. Atlanta’s rotation took a hit when ace Spencer Strider was placed on the injured list just a day before his anticipated start, throwing the team’s plans into disarray. With the series opener rapidly approaching, the Braves have yet to announce a definitive pitching strategy, leading to speculation that they may lean on a bullpen game or a spot starter to fill the void.

Atlanta's recent hot streak has been encouraging, but they enter this matchup with less stability than the visitors. The Cardinals, who finished second in the NL Central last year, have been steadier both in terms of roster health and offensive production. With Andre Pallante lined up to pitch for St. Louis, they’ll benefit from knowing their starter ahead of time, which could give them an edge in preparation and execution.

This early-season series offers a compelling clash between a team on the rise in Atlanta and a more settled St. Louis squad looking to rebound from a tough series loss. Our prediction for the Atlanta Braves vs. St. Louis Cardinals: Cards to win.

Prediction:

 

St. Louis Cardinals win both halves

+116
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St. Louis Cardinals vs Atlanta Braves Picks