San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
4/30/25 16:10
San Diego Padres

Prediction:

 

San Diego Padres wins the match

-135
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 by Carlos Zabala in MLB Picks

The Padres' bats, which had been missing from the 23rd to the 27th, reappeared at just the right time against Logan Webb, sabotaging his momentum and putting the Padres on track for another victory at Petco Park.

Arrez returned after his concussion that kept him on the 10-day disabled list. Machado and Bogaerts had a two-hit night in this series, which intensifies the fight between the Dodgers, Padres, and Giants for the NL West.

The series will resume Wednesday, and the Padres, unlike the former, will be heavy favorites at -145 for the latter. This is partly because King, who has been particularly strong at Petco Park, will be pitching. In 2025, the Padres right-hander has a 2.18 ERA and 1.06 WHIP and has also allowed three home runs so far.

The Giants will respond in Game 2 with Landen Roupp, who went without a decision in his last outing, throwing 78 pitches, 44 of which fell for strikes.

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San Francisco Giants vs San Diego Padres Form

Table

Teams % P W L
3
San Francisco Giants
San Francisco Giants
0.633 30 19 11
4
San Diego Padres
San Diego Padres
0.621 29 18 11

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Apr 27, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 26, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 25, 2025 - MLB

Texas Rangers
2 :  0
San Francisco Giants

Apr 24, 2025 - MLB

Milwaukee Brewers
5 :  6
San Francisco Giants

Apr 23, 2025 - MLB

Milwaukee Brewers
2 :  4
San Francisco Giants
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 27, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 26, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 25, 2025 - MLB

Texas Rangers
2 :  0
San Francisco Giants

Apr 24, 2025 - MLB

Milwaukee Brewers
5 :  6
San Francisco Giants

Apr 23, 2025 - MLB

Milwaukee Brewers
2 :  4
San Francisco Giants

Apr 22, 2025 - MLB

Milwaukee Brewers
11 :  3
San Francisco Giants
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Apr 20, 2025 - MLB

San Francisco Giants
4 :  5
Los Angeles Angels

Apr 19, 2025 - MLB

San Francisco Giants
3 :  2
Los Angeles Angels

Apr 18, 2025 - MLB

San Francisco Giants
0 :  2
Los Angeles Angels

Apr 17, 2025 - MLB

San Francisco Giants
4 :  6
Philadelphia Phillies

Apr 16, 2025 - MLB

San Francisco Giants
11 :  4
Philadelphia Phillies
San Diego Padres
San Diego Padres Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Apr 27, 2025 - MLB

Tampa Bay Rays
4 :  2
San Diego Padres

Apr 26, 2025 - MLB

Tampa Bay Rays
4 :  1
San Diego Padres

Apr 25, 2025 - MLB

Tampa Bay Rays
1 :  0
San Diego Padres

Apr 23, 2025 - MLB

San Diego Padres
0 :  6
Detroit Tigers

Apr 22, 2025 - MLB

San Diego Padres
2 :  0
Detroit Tigers
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Apr 27, 2025 - MLB

Tampa Bay Rays
4 :  2
San Diego Padres

Apr 26, 2025 - MLB

Tampa Bay Rays
4 :  1
San Diego Padres

Apr 25, 2025 - MLB

Tampa Bay Rays
1 :  0
San Diego Padres

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 23, 2025 - MLB

San Diego Padres
0 :  6
Detroit Tigers

Apr 22, 2025 - MLB

San Diego Padres
2 :  0
Detroit Tigers

Apr 21, 2025 - MLB

San Diego Padres
4 :  6
Detroit Tigers

Apr 20, 2025 - MLB

San Diego Padres
3 :  2
Houston Astros

Apr 19, 2025 - MLB

San Diego Padres
2 :  3
Houston Astros

Apr 18, 2025 - MLB

San Diego Padres
4 :  6
Houston Astros

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

33 %

San Diego Padres

67 %

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

Mar 9, 2025 - MLB Spring Training

San Diego Padres
4 :  7
San Francisco Giants

Mar 4, 2025 - MLB Spring Training

San Francisco Giants
1 :  1
San Diego Padres

Sep 15, 2024 - MLB

San Diego Padres
4 :  3
San Francisco Giants

Sep 14, 2024 - MLB

San Diego Padres
8 :  0
San Francisco Giants

San Francisco Giants - San Diego Padres Key Points

  1. The Padres' collective ERA this season is 2.82
  2. The Giants' FLD% is the best in MLB at 990
  3. Padres' 13-4 record at Petco Park
  4. Padres' 11-2 record as betting favorites playing at Petco Park
Up to $150 to bet on San Francisco Giants - San Diego Padres! 

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Our San Francisco Giants vs San Diego Padres Prediction

The Padres' sweep of the Rays in San Diego remains the rare exception where they didn't look good playing at home. But the return of Arraez's bat seems to have also brought a reaction from his teammates to make things difficult for one of the most dominant pitchers in recent years, Webb, in Game 1. The Padres now hold the advantage in Wednesday's pitching duel. Our prediction for Padres vs Giants is: Padres ML.

Prediction:

 

San Diego Padres wins the match

-135
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Francisco Giants vs San Diego Padres Picks
Up to $150 to bet on San Francisco Giants - San Diego Padres! 

Limited Offer. Currently at Caesars Sportsbook