San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
4/29/25 21:40
San Diego Padres

Prediction:

 

San Francisco Giants wins the match

-125
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 by Carlos Zabala in MLB Picks

A good crowd of fans is expected for the first game of the series when the Giants and Padres face off. Both teams have had spectacular starts: the Padres marked by their dominance at Petco Park, the Giants by an electrifying offense, unusually high at the beginning of the month in terms of home runs.

Each side also has players who steal the spotlight, with Tatis Jr., for the Padres, having a .346 AVG in 104 AB this season, with 8 HR and 7 stolen bases. For the Giants, Korean CF Jung Hoo Lee even has his own particular fan base, which jumped with each of the 11 doubles he hit this season and also for his high AVG of .324.

However, it seems that the Padres are the ones who are hurting in this first San Francisco-San Diego series, as they lost and were unexpectedly swept by the Rays in their own backyard, a Padres offense that had abruptly deflated since April 22 in the second inning of the series against the Tigers in Detroit. They only managed five runs in the final 25 innings, and with Giants ace Logan Webb on the mound to open the series, the series is expected to be low-scoring again.

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San Francisco Giants vs San Diego Padres Form

Table

Teams % P W L
2
San Francisco Giants
San Francisco Giants
0.655 29 19 10
5
San Diego Padres
San Diego Padres
0.607 28 17 11

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 27, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 26, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 25, 2025 - MLB

Texas Rangers
2 :  0
San Francisco Giants

Apr 24, 2025 - MLB

Milwaukee Brewers
5 :  6
San Francisco Giants

Apr 23, 2025 - MLB

Milwaukee Brewers
2 :  4
San Francisco Giants

Apr 22, 2025 - MLB

Milwaukee Brewers
11 :  3
San Francisco Giants
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 27, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 26, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 25, 2025 - MLB

Texas Rangers
2 :  0
San Francisco Giants

Apr 24, 2025 - MLB

Milwaukee Brewers
5 :  6
San Francisco Giants

Apr 23, 2025 - MLB

Milwaukee Brewers
2 :  4
San Francisco Giants

Apr 22, 2025 - MLB

Milwaukee Brewers
11 :  3
San Francisco Giants
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 20, 2025 - MLB

San Francisco Giants
4 :  5
Los Angeles Angels

Apr 19, 2025 - MLB

San Francisco Giants
3 :  2
Los Angeles Angels

Apr 18, 2025 - MLB

San Francisco Giants
0 :  2
Los Angeles Angels

Apr 17, 2025 - MLB

San Francisco Giants
4 :  6
Philadelphia Phillies

Apr 16, 2025 - MLB

San Francisco Giants
11 :  4
Philadelphia Phillies

Apr 15, 2025 - MLB

San Francisco Giants
4 :  6
Philadelphia Phillies
San Diego Padres
San Diego Padres Latest matches
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 27, 2025 - MLB

Tampa Bay Rays
4 :  2
San Diego Padres

Apr 26, 2025 - MLB

Tampa Bay Rays
4 :  1
San Diego Padres

Apr 25, 2025 - MLB

Tampa Bay Rays
1 :  0
San Diego Padres

Apr 23, 2025 - MLB

San Diego Padres
0 :  6
Detroit Tigers

Apr 22, 2025 - MLB

San Diego Padres
2 :  0
Detroit Tigers

Apr 21, 2025 - MLB

San Diego Padres
4 :  6
Detroit Tigers
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 27, 2025 - MLB

Tampa Bay Rays
4 :  2
San Diego Padres

Apr 26, 2025 - MLB

Tampa Bay Rays
4 :  1
San Diego Padres

Apr 25, 2025 - MLB

Tampa Bay Rays
1 :  0
San Diego Padres

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 23, 2025 - MLB

San Diego Padres
0 :  6
Detroit Tigers

Apr 22, 2025 - MLB

San Diego Padres
2 :  0
Detroit Tigers

Apr 21, 2025 - MLB

San Diego Padres
4 :  6
Detroit Tigers

Apr 20, 2025 - MLB

San Diego Padres
3 :  2
Houston Astros

Apr 19, 2025 - MLB

San Diego Padres
2 :  3
Houston Astros

Apr 18, 2025 - MLB

San Diego Padres
4 :  6
Houston Astros

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

33 %

San Diego Padres

67 %

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

Mar 9, 2025 - MLB Spring Training

San Diego Padres
4 :  7
San Francisco Giants

Mar 4, 2025 - MLB Spring Training

San Francisco Giants
1 :  1
San Diego Padres

Sep 15, 2024 - MLB

San Diego Padres
4 :  3
San Francisco Giants

Sep 14, 2024 - MLB

San Diego Padres
8 :  0
San Francisco Giants

Sep 13, 2024 - MLB

San Diego Padres
5 :  0
San Francisco Giants

San Francisco Giants - San Diego Padres Key Points

  1. The visiting team won the last two series between San Diego and San Francisco
  2. Giants' 6-3 record in Game 1s this season
  3. In four of five outings in April, Logan Webb pitched a quality outing
  4. Giants are 11th in MLB in doubles with 48 this season
Up to $150 to bet on San Francisco Giants - San Diego Padres! 

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Our San Francisco Giants vs San Diego Padres Prediction

The bookmakers have set the Game Total line for Tuesday's game as low as 6.5 runs. This is logical given the pitching duel between Webb and Pivetta. Webb has a mere 1.98 ERA and struck out 44 in 36.1 IP. Pivetta was an excellent acquisition, and has a 4-1 record and a very low 0.77 WHIP. Still, the Giants have a better case to take Game 1. Our prediction for Giants vs Padres is: Giants ML.

Prediction:

 

San Francisco Giants wins the match

-125
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Francisco Giants vs San Diego Padres Picks
Up to $150 to bet on San Francisco Giants - San Diego Padres! 

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