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San Francisco 49ers vs Buffalo Bills Prediction & Picks - NFL
by Dan Angell | in NFL Picks
The San Francisco 49ers (5-6 SU, 4-7 ATS) visit the Buffalo Bills (9-2 SU, 7-4 ATS) in a game that could be the 49ers’ last stand for 2024. San Francisco is fading fast, as injuries have caught up with last year’s NFC champion and left them chasing both Seattle and Arizona for supremacy in the NFC West. With the Seahawks now sitting on seven wins, the 49ers are quickly running out of time to try to catch them.
And things really don’t look good for San Francisco at the moment. The 49ers have lost back-to-back games, one of them coming against the Seahawks, and they looked totally helpless last week against Green Bay. Part of that was because of Brock Purdy going out, but things have been off with this team all year. Purdy is expected to play, but it’s anyone’s guess if he will be anywhere near full strength.
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San Francisco 49ers vs Buffalo Bills Form
Table
| Teams | % | P | W | D | L |
|---|---|---|---|---|---|
|
5
|
0.786 | 14 | 11 | 0 | 3 |
|
18
|
0.429 | 14 | 6 | 0 | 8 |
San Francisco 49ers and Buffalo Bills Latest Matches
3/6 (50%)
0/6 (0%)
3/6 (50%)
Nov 24, 2024 - NFL
Nov 17, 2024 - NFL
Nov 10, 2024 - NFL
Oct 27, 2024 - NFL
Oct 20, 2024 - NFL
Oct 10, 2024 - NFL
3/6 (50%)
0/6 (0%)
3/6 (50%)
Nov 17, 2024 - NFL
Oct 27, 2024 - NFL
Oct 20, 2024 - NFL
Oct 6, 2024 - NFL
Sep 29, 2024 - NFL
Sep 9, 2024 - NFL
2/6 (33%)
0/6 (0%)
4/6 (67%)
Nov 24, 2024 - NFL
Nov 10, 2024 - NFL
Oct 10, 2024 - NFL
Sep 22, 2024 - NFL
Sep 15, 2024 - NFL
Feb 11, 2024 - NFL
6/6 (100%)
0/6 (0%)
0/6 (0%)
Nov 17, 2024 - NFL
Nov 10, 2024 - NFL
Nov 3, 2024 - NFL
Oct 27, 2024 - NFL
Oct 20, 2024 - NFL
Oct 14, 2024 - NFL
5/6 (83%)
0/6 (0%)
1/6 (17%)
Nov 17, 2024 - NFL
Nov 3, 2024 - NFL
Oct 20, 2024 - NFL
Sep 23, 2024 - NFL
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Jan 21, 2024 - NFL
4/6 (67%)
0/6 (0%)
2/6 (33%)
Nov 10, 2024 - NFL
Oct 27, 2024 - NFL
Oct 14, 2024 - NFL
Oct 6, 2024 - NFL
Sep 29, 2024 - NFL
Sep 12, 2024 - NFL
San Francisco 49ers - Buffalo Bills Key Points
- The 49ers are 1-4 ATS in their past five games.
- The 49ers have allowed 20 points or more in seven straight games.
- The Bills have won six straight games.
- The over is 5-1 in Buffalo’s past six games.
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Our San Francisco 49ers vs Buffalo Bills Prediction
The Bills have been putting up points like nobody’s business, although that might be tough to do in these conditions. Winds could reach 30 miles per hour in Buffalo, and snow will be in the forecast. Yet Buffalo has scored 30 or more points in five straight games, and the Bills have covered in the majority of those contests. That includes a win over Kansas City, and the Bills even got a bye week after facing the Chiefs to recover mentally.
With San Francisco struggling and Buffalo hitting its stride, it seems like this is an ideal spot for the Bills to make a statement. They’re on national television, they’re in top shape and they’re chasing the Chiefs to try to make the playoffs come through western New York. The Bills can also play fairly freely, as they don’t have to worry about getting caught in their division. With the lack of pressure, the Bills should be in good shape. Our prediction for San Francisco vs. Buffalo is Bills -6.5.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
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