USA - NFL

San Francisco 49ers
05 Jan 2025 16:25
Arizona Cardinals

Prediction:

 

49ers ML

+180
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San Francisco 49ers vs Arizona Cardinals Prediction & Picks - NFL

 by Travis Pulver in NFL Picks

The San Francisco 49er will close out a disappointing season with a trip to Arizona to take on the Cardinals at State Farm Stadium in Glendale. Kickoff is scheduled for 4:25 p.m. ET. With both teams already eliminated from the postseason, both teams will be looking to end the season on a positive note after stumbling down the stretch.

Arizona will have more of their regular players available for the game, but the 49ers may be a little more motivated to bring their ‘A’ game. Jauan Jennings is 77 yards short of his first 1,000-yard season. After missing much of his rookie season recovering from a gunshot wound, he’s probably eager to show the team and fans what he’s capable of.

But the 49ers will not have Brock Purdy available as he recovers from an elbow injury. While Brandon Allen got the start earlier in the season when Purdy couldn’t go, Joshua Dobbs will start this week. Joshua Dobbs is the more athletic of the two and could give the offense an added dimension. Since he’s on a one-year contract, a solid performance in this game could go a long way to making sure he makes a roster next season.

San Francisco 49ers vs Arizona Cardinals Form

Table

Teams % P W D L
17
Arizona Cardinals
Arizona Cardinals
0.471 17 8 0 9
22
San Francisco 49ers
San Francisco 49ers
0.353 17 6 0 11

San Francisco 49ers and Arizona Cardinals Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
L L W L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Dec 30, 2024 - NFL

Detroit Lions
40 :  34
San Francisco 49ers

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Dec 12, 2024 - NFL

Los Angeles Rams
12 :  6
San Francisco 49ers

Dec 8, 2024 - NFL

Chicago Bears
13 :  38
San Francisco 49ers

Dec 1, 2024 - NFL

San Francisco 49ers
10 :  35
Buffalo Bills

Nov 24, 2024 - NFL

San Francisco 49ers
10 :  38
Green Bay Packers
L W L W L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 30, 2024 - NFL

Detroit Lions
40 :  34
San Francisco 49ers

Dec 12, 2024 - NFL

Los Angeles Rams
12 :  6
San Francisco 49ers

Dec 8, 2024 - NFL

Chicago Bears
13 :  38
San Francisco 49ers

Nov 17, 2024 - NFL

Seattle Seahawks
20 :  17
San Francisco 49ers

Oct 27, 2024 - NFL

Dallas Cowboys
24 :  30
San Francisco 49ers

Oct 20, 2024 - NFL

Kansas City Chiefs
28 :  18
San Francisco 49ers
L W W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 22, 2024 - NFL

San Francisco 49ers
17 :  29
Miami Dolphins

Dec 1, 2024 - NFL

San Francisco 49ers
10 :  35
Buffalo Bills

Nov 24, 2024 - NFL

San Francisco 49ers
10 :  38
Green Bay Packers

Nov 10, 2024 - NFL

San Francisco 49ers
23 :  20
Tampa Bay Buccaneers

Oct 10, 2024 - NFL

San Francisco 49ers
36 :  24
Seattle Seahawks

Sep 22, 2024 - NFL

San Francisco 49ers
24 :  27
Los Angeles Rams
Arizona Cardinals
Arizona Cardinals Latest matches
L L L W L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Dec 1, 2024 - NFL

Arizona Cardinals
22 :  23
Minnesota Vikings

Nov 24, 2024 - NFL

Arizona Cardinals
6 :  16
Seattle Seahawks
L W W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 15, 2024 - NFL

New England Patriots
17 :  30
Arizona Cardinals

Dec 8, 2024 - NFL

Seattle Seahawks
30 :  18
Arizona Cardinals

Nov 10, 2024 - NFL

New York Jets
6 :  31
Arizona Cardinals

Nov 3, 2024 - NFL

Chicago Bears
9 :  29
Arizona Cardinals

Oct 21, 2024 - NFL

Los Angeles Chargers
15 :  17
Arizona Cardinals

Sep 29, 2024 - NFL

Washington Commanders
42 :  14
Arizona Cardinals
L W L L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Dec 22, 2024 - NFL

Arizona Cardinals
30 :  36
Carolina Panthers

Dec 1, 2024 - NFL

Arizona Cardinals
22 :  23
Minnesota Vikings

Nov 24, 2024 - NFL

Arizona Cardinals
6 :  16
Seattle Seahawks

Oct 27, 2024 - NFL

Arizona Cardinals
28 :  27
Miami Dolphins

Oct 13, 2024 - NFL

Arizona Cardinals
13 :  34
Green Bay Packers

San Francisco 49ers against Arizona Cardinals : Head to Head (H2H)

San Francisco 49ers

75 %

Draw

0 %

Arizona Cardinals

25 %

Oct 6, 2024 - NFL

Arizona Cardinals
24 :  23
San Francisco 49ers

Dec 17, 2023 - NFL

San Francisco 49ers
45 :  29
Arizona Cardinals

Oct 1, 2023 - NFL

Arizona Cardinals
16 :  35
San Francisco 49ers

Nov 21, 2022 - NFL

San Francisco 49ers
38 :  10
Arizona Cardinals

San Francisco 49ers - Arizona Cardinals Key Points

  1. San Francisco has lost five of their last seven, while the Cardinals have lost six of their last seven
  2. The 49ers lead the all-time series vs. the Cardinals 36-30; San Francisco has won six of the last ten.
  3. Arizona has not defeated the 49ers at home since the 2021 season.
  4. The OVER is 7-8-1 for Arizona this season and 9-7 for San Francisco.

Our San Francisco 49ers vs Arizona Cardinals Prediction

The Cardinals should be the betting favorite simply because Kyler Murray is playing and Brock Purdy isn’t. However, Murray hasn’t exactly been lighting up opposing secondaries in recent weeks. Yes, he had 300+ yards against the Rams last week, but he also had two picks and only scored nine points. Joshua Dobbs’ athleticism could give the offense the spark it needs to close the season with a win. With the potential Dobbs, Jennings, and Pearsall have for big performances in this game, we see the San Francisco ML as having a lot of value.

Our 49ers vs. Cardinals Prediction: 49ers ML

Prediction:

 

49ers ML

+180
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San Francisco 49ers vs Arizona Cardinals Picks