San Diego Padres vs Houston Astros Prediction & Picks - MLB

USA - MLB

San Diego Padres
4/18/25 20:10
Houston Astros

Prediction:

 

San Diego ML

+130
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 by Travis Pulver | in MLB Picks

It will not be easy to get back on the right side of the scoreboard against a red-hot San Diego Padres team, but the Houston Astros will try in Game One of a three-game home series tonight at Daiken Park in Houston, TX. First pitch is scheduled for 8:10 p.m. EST.

Houston has been struggling to get on track this season; through 18 games, they have yet to win two in a row. The only time they have lost 2+ in a row was a three-game sweep vs. San Francisco. They have one of the lowest team batting averages of the season at .216. But their pitching staff has been one of the best in baseball with a 3.73 ERA (top ten) and 181 strikeouts (fourth best). San Diego, on the other hand, has the best batting average in the league at .274. Their pitching staff has also been top-notch, with a 2.56 ERA and a 1.07 WHIP, while holding opponents to a .193 batting average.

San Diego will turn to Kyle Hart to start the game on the mound for the Padres. In three starts, he’s gone 2-0 with a 5.40 ERA and 1.11 WHIP. Ryan Gusto will get the start for Houston. He appears to be more of an opener, having gone just 2, 2, 3,1, and 4 innings in five starts.

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San Diego Padres vs Houston Astros Form

Table

Teams % P W L
1
San Diego Padres
San Diego Padres
0.75 20 15 5
18
Houston Astros
Houston Astros
0.474 19 9 10

San Diego Padres and Houston Astros Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Colorado Rockies
0 :  6
San Diego Padres

Apr 12, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Apr 11, 2025 - MLB

Colorado Rockies
0 :  8
San Diego Padres
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Colorado Rockies
0 :  6
San Diego Padres

Apr 12, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Apr 11, 2025 - MLB

Colorado Rockies
0 :  8
San Diego Padres
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 9, 2025 - MLB

San Diego Padres
2 :  1
Athletics

Apr 8, 2025 - MLB

San Diego Padres
4 :  10
Athletics

Apr 7, 2025 - MLB

San Diego Padres
5 :  4
Athletics

Apr 6, 2025 - MLB

San Diego Padres
8 :  7
Chicago Cubs

Apr 5, 2025 - MLB

San Diego Padres
1 :  7
Chicago Cubs

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs
Houston Astros
Houston Astros Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

Houston Astros
1 :  4
St. Louis Cardinals

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 13, 2025 - MLB

Los Angeles Angels
3 :  7
Houston Astros

Apr 12, 2025 - MLB

Los Angeles Angels
4 :  1
Houston Astros

Apr 11, 2025 - MLB

Los Angeles Angels
3 :  14
Houston Astros
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 13, 2025 - MLB

Los Angeles Angels
3 :  7
Houston Astros

Apr 12, 2025 - MLB

Los Angeles Angels
4 :  1
Houston Astros

Apr 11, 2025 - MLB

Los Angeles Angels
3 :  14
Houston Astros

Apr 2, 2025 - MLB

San Francisco Giants
6 :  3
Houston Astros

Apr 1, 2025 - MLB

San Francisco Giants
3 :  1
Houston Astros

Mar 31, 2025 - MLB

San Francisco Giants
7 :  2
Houston Astros
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 16, 2025 - MLB

Houston Astros
1 :  4
St. Louis Cardinals

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 9, 2025 - MLB

Houston Astros
6 :  7
Seattle Mariners

Apr 8, 2025 - MLB

Houston Astros
2 :  1
Seattle Mariners

Apr 7, 2025 - MLB

Houston Astros
3 :  4
Seattle Mariners

San Diego Padres against Houston Astros : Head to Head (H2H)

San Diego Padres

83 %

Houston Astros

17 %

Sep 18, 2024 - MLB

Houston Astros
0 :  4
San Diego Padres

Sep 17, 2024 - MLB

Houston Astros
4 :  3
San Diego Padres

Sep 16, 2024 - MLB

Houston Astros
1 :  3
San Diego Padres

Sep 4, 2021 - MLB

Houston Astros
2 :  10
San Diego Padres

Aug 23, 2020 - MLB

Houston Astros
3 :  5
San Diego Padres

Aug 22, 2020 - MLB

Houston Astros
2 :  13
San Diego Padres

San Diego Padres - Houston Astros Key Points

  1. Houston leads the all-time series vs. San Diego 320-296.
  2. The Padres have gone 10-5 vs. the Astros over the last four seasons.
  3. This will be the first time either pitcher has faced the opposing team.
  4. Houston has lost 14 of their last 15 games following a road loss.
Up to $150 to bet on San Diego Padres - Houston Astros! 

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Our San Diego Padres vs Houston Astros Prediction

If the pattern holds, Houston is due for a win, but they are facing a decent pitcher against a potent lineup. Tack on the suspect production coming from their lineup and it becomes a lot harder to justify getting behind the Astros. However, if this is a bullpen game for Houston, the ‘pen’s ERA is 2.94, and they have been playing better at home….

Our Astros vs. Padres Pick: San Diego ML

Prediction:

 

San Diego ML

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Diego Padres vs Houston Astros Picks
Up to $150 to bet on San Diego Padres - Houston Astros! 

Limited Offer. Currently at Caesars Sportsbook