San Diego Padres vs Detroit Tigers Prediction & Picks - MLB

USA - MLB

San Diego Padres
4/21/25 18:40
Detroit Tigers

Prediction:

 

Tigers -1.5 Runs

+154
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 by Lou Aguila | in MLB Picks

The Detroit Tigers look to sustain their momentum as they kick off a new series with the skidding San Diego Padres starting on Monday at Comerica Park.

The Tigers took 3 out of 4 in the series with the Kansas City Royals to improve their record to 13-9, No.1 in the American League Central. They may have lost the series finale 3-4 in extra innings, but that won’t diminish a successful weekend for Detroit, who has just lowered their team ERA to 3.12.

The Padres won Game 3 vs. the Houston Astros, 3-2, on Sunday, but losing three of their last five games has brought down their record to 16-6, 0.5 games ahead of the LA Dodgers (16-5) in the National League West. San Diego is still lethal batting team, averaging .276 with 97 runs this season. They still own the second-best ERA in baseball at 2.74 despite their recent hiccups but they better bring their A-game against the Tigers, who also possess the depth to match their firepower on the mound.

San Diego Padres vs Detroit Tigers Form

Table

Teams % P W L
1
San Diego Padres
San Diego Padres
0.727 22 16 6
6
Detroit Tigers
Detroit Tigers
0.591 22 13 9

San Diego Padres and Detroit Tigers Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2025 - MLB

San Diego Padres
3 :  2
Houston Astros

Apr 19, 2025 - MLB

San Diego Padres
2 :  3
Houston Astros

Apr 18, 2025 - MLB

San Diego Padres
4 :  6
Houston Astros

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Colorado Rockies
0 :  6
San Diego Padres

Apr 12, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Apr 11, 2025 - MLB

Colorado Rockies
0 :  8
San Diego Padres
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2025 - MLB

San Diego Padres
3 :  2
Houston Astros

Apr 19, 2025 - MLB

San Diego Padres
2 :  3
Houston Astros

Apr 18, 2025 - MLB

San Diego Padres
4 :  6
Houston Astros

Apr 9, 2025 - MLB

San Diego Padres
2 :  1
Athletics

Apr 8, 2025 - MLB

San Diego Padres
4 :  10
Athletics

Apr 7, 2025 - MLB

San Diego Padres
5 :  4
Athletics
Detroit Tigers
Detroit Tigers Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2025 - MLB

Kansas City Royals
4 :  3
Detroit Tigers

Apr 19, 2025 - MLB

Kansas City Royals
1 :  3
Detroit Tigers

Apr 18, 2025 - MLB

Kansas City Royals
3 :  7
Detroit Tigers

Apr 17, 2025 - MLB

Kansas City Royals
1 :  6
Detroit Tigers

Apr 16, 2025 - MLB

Detroit Tigers
1 :  5
Milwaukee Brewers

Apr 15, 2025 - MLB

Detroit Tigers
0 :  5
Milwaukee Brewers
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 20, 2025 - MLB

Kansas City Royals
4 :  3
Detroit Tigers

Apr 19, 2025 - MLB

Kansas City Royals
1 :  3
Detroit Tigers

Apr 18, 2025 - MLB

Kansas City Royals
3 :  7
Detroit Tigers

Apr 17, 2025 - MLB

Kansas City Royals
1 :  6
Detroit Tigers

Apr 9, 2025 - MLB

New York Yankees
4 :  3
Detroit Tigers

Apr 8, 2025 - MLB

New York Yankees
0 :  5
Detroit Tigers
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

Detroit Tigers
1 :  5
Milwaukee Brewers

Apr 15, 2025 - MLB

Detroit Tigers
0 :  5
Milwaukee Brewers

Apr 14, 2025 - MLB

Detroit Tigers
9 :  1
Milwaukee Brewers

Apr 13, 2025 - MLB

Detroit Tigers
1 :  5
Minnesota Twins

Apr 12, 2025 - MLB

Detroit Tigers
4 :  0
Minnesota Twins

Apr 11, 2025 - MLB

Detroit Tigers
7 :  6
Minnesota Twins

San Diego Padres against Detroit Tigers : Head to Head (H2H)

San Diego Padres

67 %

Detroit Tigers

33 %

Sep 5, 2024 - MLB

Detroit Tigers
4 :  3
San Diego Padres

Sep 4, 2024 - MLB

Detroit Tigers
5 :  6
San Diego Padres

Sep 2, 2024 - MLB

Detroit Tigers
0 :  3
San Diego Padres

San Diego Padres - Detroit Tigers Key Points

  1. San Diego is 14-6 SU in its last 20 games.
  2. San Diego is 3-6 SU in its last 9 games when playing on the road against Detroit.
  3. Detroit is 11-5 SU in its last 16 games.
  4. Detroit is 8-2 SU in its last 10 games at home.

Our San Diego Padres vs Detroit Tigers Prediction

Fearless Forecast: The Tigers continue to roll at home, downing the Padres with their energized offense

I would pick the Tigers to stay cooking at Comerica Park. Not only are they 8-2 against the spread in their last 10 home games, but Detroit is putting in a better batting average in their last five games than San Diego did in their last five. The Tigers are averaging 4.2 runs, whereas the Padres are struggling with 2.8 runs per game in their 5-game stretch. Keider Montero had a horrific stint vs. the Brewers, allowing five earned runs in 5.0 innings. But I am still optimistic that he can regain his mojo against the struggling Padres’ batters in Game 1. Padres’ starter Randy Vasquez has been nice this season with a 1-1 record and 1.74 ERA, but there’s a good chance he will get an L again not because he’s bad but the Padres’ offense is on a slump right now that they just can’t get him enough runs to beat another playoff-caliber team. Our betting prediction for Detroit Tigers vs. San Diego Padres: Tigers -1.5 Runs.

Prediction:

 

Tigers -1.5 Runs

+154
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San Diego Padres vs Detroit Tigers Picks