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by Lou Aguila in MLB Picks
The San Diego Padres look to jump back into the winner’s circle as they gun for revenge against the Chicago Cubs at Wrigley Field on Saturday.
The Padres’ unbeaten run to start the 2025 MLB season ended on Friday after bowing to the Cubs, 1-3. San Diego had no answer to Cubs’ hurler Shoto Imanaga, who conceded one run in eight innings. The Padres, batting .298/.369/.440 with 36 runs this season, will be counting on Nick Pivetta (1-0, 0.00 ERA) to get them back into their winning groove.
The Cubs have won their last four games, including Friday’s big win over the Padres. Chicago banked on their pitching all night, led by Imanaga, to contain the Padres’ high-powered offense. The Cubs hope starter Matthew Boyd can sustain their dominance on the mound in Saturday’s Game 2.
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San Diego Padres vs Chicago Cubs Form
Table
| Teams | % | P | W | L |
|---|---|---|---|---|
|
5
|
0.607 | 28 | 17 | 11 |
|
6
|
0.586 | 29 | 17 | 12 |
San Diego Padres and Chicago Cubs Latest Matches
5/6 (83%)
1/6 (17%)
Apr 4, 2025 - MLB
Apr 2, 2025 - MLB
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
Mar 30, 2025 - MLB
Mar 29, 2025 - MLB
6/6 (100%)
0/6 (0%)
Apr 2, 2025 - MLB
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
Mar 30, 2025 - MLB
Mar 29, 2025 - MLB
Mar 28, 2025 - MLB
2/6 (33%)
4/6 (67%)
Apr 4, 2025 - MLB
Mar 23, 2025 - MLB Spring Training
Mar 22, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 18, 2025 - MLB Spring Training
Mar 16, 2025 - MLB Spring Training
5/6 (83%)
1/6 (17%)
Apr 4, 2025 - MLB
Apr 2, 2025 - MLB
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
Mar 30, 2025 - MLB
Mar 29, 2025 - MLB
2/6 (33%)
4/6 (67%)
Apr 4, 2025 - MLB
Mar 25, 2025 - MLB Spring Training
Mar 24, 2025 - MLB Spring Training
Mar 23, 2025 - MLB Spring Training
Mar 22, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
4/6 (67%)
2/6 (33%)
Apr 2, 2025 - MLB
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
Mar 30, 2025 - MLB
Mar 29, 2025 - MLB
Mar 28, 2025 - MLB
San Diego Padres against Chicago Cubs : Head to Head (H2H)
33 %
67 %
Apr 4, 2025 - MLB
Mar 21, 2025 - MLB Spring Training
Mar 4, 2025 - MLB Spring Training
Feb 24, 2025 - MLB Spring Training
May 8, 2024 - MLB
May 7, 2024 - MLB
San Diego Padres - Chicago Cubs Key Points
- Chicago Cubs are 5-1 SU in their last 6 games.
- Chicago Cubs are 4-1 SU in their last 5 games played in April.
- San Diego are 1-4 SU in their last 5 games on the road.
- San Diego are 7-1 SU in their last 8 games.
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Our San Diego Padres vs Chicago Cubs Prediction
It won’t be easy to repeat against the Padres, but I believe the Cubs have what it takes to pull it off. Boyd is coming off a strong start by blanking the Arizona Diamondbacks through five innings of a 10-6 loss. However, the key to a Cubs victory would heavily depend on the performance bullpen, who had held a 6.00+ ERA this season before shutting out the Padres in the final two innings of Game 1. Our betting prediction for San Diego Padres vs. Chicago Cubs: Cubs will win.
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
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