San Diego Padres vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

San Diego Padres
4/5/25 14:20
Chicago Cubs

Prediction:

 

Chicago Cubs will win

-120
$1500 offered for betting!

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 by Lou Aguila | in MLB Picks

The San Diego Padres look to jump back into the winner’s circle as they gun for revenge against the Chicago Cubs at Wrigley Field on Saturday.

The Padres’ unbeaten run to start the 2025 MLB season ended on Friday after bowing to the Cubs, 1-3. San Diego had no answer to Cubs’ hurler Shoto Imanaga, who conceded one run in eight innings. The Padres, batting .298/.369/.440 with 36 runs this season, will be counting on Nick Pivetta (1-0, 0.00 ERA) to get them back into their winning groove.

The Cubs have won their last four games, including Friday’s big win over the Padres. Chicago banked on their pitching all night, led by Imanaga, to contain the Padres’ high-powered offense. The Cubs hope starter Matthew Boyd can sustain their dominance on the mound in Saturday’s Game 2.

San Diego Padres vs Chicago Cubs Form

Table

Teams % P W L
2
San Diego Padres
San Diego Padres
0.875 8 7 1
9
Chicago Cubs
Chicago Cubs
0.6 10 6 4

San Diego Padres and Chicago Cubs Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres
W L W L D L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Mar 23, 2025 - MLB Spring Training

San Diego Padres
5 :  5
Arizona Diamondbacks

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

Mar 16, 2025 - MLB Spring Training

San Diego Padres
4 :  2
Los Angeles Angels
Chicago Cubs
Chicago Cubs Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Apr 2, 2025 - MLB

Chicago Cubs
10 :  2
Athletics

Apr 1, 2025 - MLB

Chicago Cubs
7 :  4
Athletics

Mar 31, 2025 - MLB

Chicago Cubs
18 :  3
Athletics

Mar 30, 2025 - MLB

Chicago Cubs
6 :  10
Arizona Diamondbacks

Mar 29, 2025 - MLB

Chicago Cubs
4 :  3
Arizona Diamondbacks
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Mar 25, 2025 - MLB Spring Training

Atlanta Braves
2 :  4
Chicago Cubs

Mar 24, 2025 - MLB Spring Training

Atlanta Braves
13 :  4
Chicago Cubs

Mar 23, 2025 - MLB Spring Training

Athletics
8 :  1
Chicago Cubs

Mar 22, 2025 - MLB Spring Training

Colorado Rockies
7 :  3
Chicago Cubs

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 2, 2025 - MLB

Chicago Cubs
10 :  2
Athletics

Apr 1, 2025 - MLB

Chicago Cubs
7 :  4
Athletics

Mar 31, 2025 - MLB

Chicago Cubs
18 :  3
Athletics

Mar 30, 2025 - MLB

Chicago Cubs
6 :  10
Arizona Diamondbacks

Mar 29, 2025 - MLB

Chicago Cubs
4 :  3
Arizona Diamondbacks

Mar 28, 2025 - MLB

Chicago Cubs
1 :  8
Arizona Diamondbacks

San Diego Padres against Chicago Cubs : Head to Head (H2H)

San Diego Padres

33 %

Chicago Cubs

67 %

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 4, 2025 - MLB Spring Training

San Diego Padres
1 :  16
Chicago Cubs

Feb 24, 2025 - MLB Spring Training

Chicago Cubs
10 :  5
San Diego Padres

May 8, 2024 - MLB

San Diego Padres
3 :  0
Chicago Cubs

May 7, 2024 - MLB

San Diego Padres
2 :  3
Chicago Cubs

San Diego Padres - Chicago Cubs Key Points

  1. Chicago Cubs are 5-1 SU in their last 6 games.
  2. Chicago Cubs are 4-1 SU in their last 5 games played in April.
  3. San Diego are 1-4 SU in their last 5 games on the road.
  4. San Diego are 7-1 SU in their last 8 games.

Our San Diego Padres vs Chicago Cubs Prediction

It won’t be easy to repeat against the Padres, but I believe the Cubs have what it takes to pull it off. Boyd is coming off a strong start by blanking the Arizona Diamondbacks through five innings of a 10-6 loss. However, the key to a Cubs victory would heavily depend on the performance bullpen, who had held a 6.00+ ERA this season before shutting out the Padres in the final two innings of Game 1. Our betting prediction for San Diego Padres vs. Chicago Cubs: Cubs will win.

Prediction:

 

Chicago Cubs will win

-120
$1500 offered for betting!

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San Diego Padres vs Chicago Cubs Picks