San Diego Padres vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

San Diego Padres
4/4/25 14:20
Chicago Cubs

Prediction:

 

Cubs -1.5.

+140
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 by Carlos Zabala | in MLB Picks

In Sacramento, the Cubs' bats continued to be hot to start 2025, especially Seiya Susuki, who hit three home runs on April 1 and 2 before the team's debut at Wrigley Field against the undefeated Padres. All in all, since the Tokyo Series, arriving in Chicago with a 5-4 record, including nine road games against the Dodgers and D-backs, is a good record.

The Cubs are third in the MLB in home runs with 14 and seventh in team OBP with 368. However, the team appears to be burdened with the same bullpen issues that marred their 2024 season now in 2025.

Meanwhile, the Padres, unlike the Cubs, will be heading to Petco Park for the first time this season, undefeated and with a lineup whose nearly all members have responded well to start the year. Merill recently finalized his contract extension with the Padres, who secured him a nine-year contract as one of the faces of the franchise. Merill already responded with a .417 AVG to start the season and hit a home run in the final game against the Guardians.

San Diego Padres vs Chicago Cubs Form

Table

Teams % P W L
1
San Diego Padres
San Diego Padres
1 7 7 0
13
Chicago Cubs
Chicago Cubs
0.556 9 5 4

San Diego Padres and Chicago Cubs Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres
W W L W L D
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 23, 2025 - MLB Spring Training

San Diego Padres
5 :  5
Arizona Diamondbacks

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

Mar 16, 2025 - MLB Spring Training

San Diego Padres
4 :  2
Los Angeles Angels

Mar 15, 2025 - MLB Spring Training

San Diego Padres
8 :  3
Seattle Mariners
Chicago Cubs
Chicago Cubs Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 2, 2025 - MLB

Chicago Cubs
10 :  2
Athletics

Apr 1, 2025 - MLB

Chicago Cubs
7 :  4
Athletics

Mar 31, 2025 - MLB

Chicago Cubs
18 :  3
Athletics

Mar 30, 2025 - MLB

Chicago Cubs
6 :  10
Arizona Diamondbacks

Mar 29, 2025 - MLB

Chicago Cubs
4 :  3
Arizona Diamondbacks

Mar 28, 2025 - MLB

Chicago Cubs
1 :  8
Arizona Diamondbacks
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Mar 25, 2025 - MLB Spring Training

Atlanta Braves
2 :  4
Chicago Cubs

Mar 24, 2025 - MLB Spring Training

Atlanta Braves
13 :  4
Chicago Cubs

Mar 23, 2025 - MLB Spring Training

Athletics
8 :  1
Chicago Cubs

Mar 22, 2025 - MLB Spring Training

Colorado Rockies
7 :  3
Chicago Cubs

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 19, 2025 - MLB

Los Angeles Dodgers
6 :  3
Chicago Cubs
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 2, 2025 - MLB

Chicago Cubs
10 :  2
Athletics

Apr 1, 2025 - MLB

Chicago Cubs
7 :  4
Athletics

Mar 31, 2025 - MLB

Chicago Cubs
18 :  3
Athletics

Mar 30, 2025 - MLB

Chicago Cubs
6 :  10
Arizona Diamondbacks

Mar 29, 2025 - MLB

Chicago Cubs
4 :  3
Arizona Diamondbacks

Mar 28, 2025 - MLB

Chicago Cubs
1 :  8
Arizona Diamondbacks

San Diego Padres against Chicago Cubs : Head to Head (H2H)

San Diego Padres

50 %

Chicago Cubs

50 %

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 4, 2025 - MLB Spring Training

San Diego Padres
1 :  16
Chicago Cubs

Feb 24, 2025 - MLB Spring Training

Chicago Cubs
10 :  5
San Diego Padres

May 8, 2024 - MLB

San Diego Padres
3 :  0
Chicago Cubs

May 7, 2024 - MLB

San Diego Padres
2 :  3
Chicago Cubs

May 6, 2024 - MLB

San Diego Padres
6 :  3
Chicago Cubs

San Diego Padres - Chicago Cubs Key Points

  1. Betting odds are the Padres' ATS record is 6-1 this season
  2. Tatis Jr. averaged .423 to start the season with the Padres
  3. Cubs are averaging 6.7 runs this season
  4. Padres' pitching is second-best BAA in MLB at .166

Our San Diego Padres vs Chicago Cubs Prediction

Even with a 7-0 record and superb performances from the Padres' starting and relief pitching, bookmakers predict that Friday's game could very well be San Diego's first loss of the season. The Vásquez-Imanaga pitching duel seems to suit the home team. Imanaga pitched 4 scoreless innings against the Dodgers in Tokyo and then earned his first W of the season pitching 7 innings against the Diamondbacks. Our prediction for Cubs vs Padres is: Cubs -1.5.

Prediction:

 

Cubs -1.5.

+140
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San Diego Padres vs Chicago Cubs Picks