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by Lou Aguila | in MLB Picks
The Minnesota Twins and the St. Louis Cardinals look to start their season on a strong note, kicking off their season-opening series at Busch Stadium on Thursday.
The Twins have won their last three games of Spring Training, flexing their improved offense against the Boston Red Sox 9-3, the Pittsburgh Pirates 5-1, and the Colorado Rockies 5-3. Pablo Lopez will step onto the mound as the opening-day starter for Minnesota, getting the nod after posting 15 wins with a 4.08 ERA last season.
The Cardinals have gone 3-2 in their last five games of Spring Training. They dropped their last exhibition game against the Washington Nationals 1-2 after Jack Sinclair allowed zero runs in 5.5 pitched innings. 13-9 with a 3.84 ERA last season, Sonny Gray will start for St. Louis on opening day.
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Minnesota Twins vs St. Louis Cardinals Form
Table
Teams | % | P | W | L |
---|---|---|---|---|
1
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1 | 2 | 2 | 0 |
26
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0 | 2 | 0 | 2 |
Minnesota Twins and St. Louis Cardinals Latest Matches

4/6 (67%)
2/6 (33%)
Mar 25, 2025 - MLB Spring Training
Mar 24, 2025 - MLB Spring Training
Mar 23, 2025 - MLB Spring Training
Mar 22, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 20, 2025 - MLB Spring Training
3/6 (50%)
3/6 (50%)
Mar 25, 2025 - MLB Spring Training
Mar 24, 2025 - MLB Spring Training
Mar 22, 2025 - MLB Spring Training
Mar 20, 2025 - MLB Spring Training
Mar 18, 2025 - MLB Spring Training
Mar 16, 2025 - MLB Spring Training
2/6 (33%)
4/6 (67%)
Mar 23, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 17, 2025 - MLB Spring Training
Mar 15, 2025 - MLB Spring Training
Mar 14, 2025 - MLB Spring Training
Mar 12, 2025 - MLB Spring Training

3/6 (50%)
3/6 (50%)
Mar 24, 2025 - MLB Spring Training
Mar 23, 2025 - MLB Spring Training
Mar 22, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 19, 2025 - MLB Spring Training
3/6 (50%)
3/6 (50%)
Mar 23, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 19, 2025 - MLB Spring Training
Mar 18, 2025 - MLB Spring Training
Mar 15, 2025 - MLB Spring Training
Mar 12, 2025 - MLB Spring Training
3/6 (50%)
3/6 (50%)
Mar 24, 2025 - MLB Spring Training
Mar 22, 2025 - MLB Spring Training
Mar 21, 2025 - MLB Spring Training
Mar 17, 2025 - MLB Spring Training
Mar 16, 2025 - MLB Spring Training
Mar 14, 2025 - MLB Spring Training
Minnesota Twins against St. Louis Cardinals : Head to Head (H2H)
50 %
50 %
Aug 25, 2024 - MLB
Aug 24, 2024 - MLB
Aug 23, 2024 - MLB
Aug 3, 2023 - MLB
Sep 8, 2020 - MLB
Sep 8, 2020 - MLB
Minnesota Twins - St. Louis Cardinals Key Points
- St. Louis are 2-5 SU in their last 7 games against an opponent in the American League.
- Minnesota are 1-7 SU in their last 8 games.
- Minnesota are 2-8 SU in their last 10 games on the road.
- St. Louis are 6-2 SU in their last 8 games.
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Our Minnesota Twins vs St. Louis Cardinals Prediction
Minnesota Twins’ decision to start Pablo Lopez on opening days put them in a strong position to bag a straight-up and ATS win on Day 1 of the MLB 2025. Lopez has performed scintillating in his last two faceoffs with the Cardinals, throwing one earned run with 5 Ks on August 1 and a shutout with 9 strikeouts in a 6-0 win on August 24. Meanwhile, Cardinals starter Sonny Gray has lost two of his last three starts vs. Twins, including his previous duel with Lopez where he allowed five earned runs over six innings. Minnesota has scored 19 runs in their previous three games; St Louis has totaled 11 runs in their last three. Our betting prediction for Minnesota Twins vs. St. Louis Cardinals: Twins -1.5 runs.
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