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Houston Astros vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Houston Astros
4/16/25 12:15
St. Louis Cardinals

Prediction:

 

Cardinals will win

+100
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 by Lou Aguila | in MLB Picks

The Houston Astros aim for their first win streak this season in Wednesday’s series-finale against the St. Louis Cardinals at Busch Stadium.

The up and down pattern continues for the Astros, who bounced back from 3-8 loss in Game 1 vs. the Cardinals by bagging their first team shutout win of the season. Hunter Brown was sensational on the mound for six innings, allowing four hits and two walks to garner his second consecutive shutout. Houston is sporting a 3.92 ERA, which falls in the middle of the pack, but their bullpen has figured it out in the last five games, surrendering a 1.42 ERA.

The Game 2 loss snapped the Cardinals’ two-game winning run, absorbing their first shutout loss this year. Batting .280 with 5.3 runs per game, St. Louis could only produce six hits against the Astros’ impeccable pitching on Tuesday.

Houston Astros vs St. Louis Cardinals Form

Table

Teams % P W L
18
St. Louis Cardinals
St. Louis Cardinals
0.471 17 8 9
18
Houston Astros
Houston Astros
0.471 17 8 9

Houston Astros and St. Louis Cardinals Latest Matches

Houston Astros
Houston Astros Latest matches
W W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 13, 2025 - MLB

Los Angeles Angels
3 :  7
Houston Astros

Apr 12, 2025 - MLB

Los Angeles Angels
4 :  1
Houston Astros

Apr 11, 2025 - MLB

Los Angeles Angels
3 :  14
Houston Astros

Apr 9, 2025 - MLB

Houston Astros
6 :  7
Seattle Mariners
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 13, 2025 - MLB

Los Angeles Angels
3 :  7
Houston Astros

Apr 12, 2025 - MLB

Los Angeles Angels
4 :  1
Houston Astros

Apr 11, 2025 - MLB

Los Angeles Angels
3 :  14
Houston Astros

Apr 2, 2025 - MLB

San Francisco Giants
6 :  3
Houston Astros

Apr 1, 2025 - MLB

San Francisco Giants
3 :  1
Houston Astros

Mar 31, 2025 - MLB

San Francisco Giants
7 :  2
Houston Astros
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 9, 2025 - MLB

Houston Astros
6 :  7
Seattle Mariners

Apr 8, 2025 - MLB

Houston Astros
2 :  1
Seattle Mariners

Apr 7, 2025 - MLB

Houston Astros
3 :  4
Seattle Mariners

Apr 6, 2025 - MLB

Houston Astros
9 :  7
Minnesota Twins
St. Louis Cardinals
St. Louis Cardinals Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 13, 2025 - MLB

Philadelphia Phillies
0 :  7
St. Louis Cardinals

Apr 12, 2025 - MLB

Philadelphia Phillies
4 :  1
St. Louis Cardinals

Apr 11, 2025 - MLB

Philadelphia Phillies
0 :  2
St. Louis Cardinals

Apr 9, 2025 - MLB

St. Louis Cardinals
1 :  2
Pittsburgh Pirates
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Apr 13, 2025 - MLB

Philadelphia Phillies
0 :  7
St. Louis Cardinals

Apr 12, 2025 - MLB

Philadelphia Phillies
4 :  1
St. Louis Cardinals

Apr 11, 2025 - MLB

Philadelphia Phillies
0 :  2
St. Louis Cardinals

Apr 2, 2025 - MLB

Los Angeles Angels
5 :  12
St. Louis Cardinals
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 9, 2025 - MLB

St. Louis Cardinals
1 :  2
Pittsburgh Pirates

Apr 8, 2025 - MLB

St. Louis Cardinals
5 :  3
Pittsburgh Pirates

Apr 7, 2025 - MLB

St. Louis Cardinals
4 :  8
Pittsburgh Pirates

Apr 6, 2025 - MLB

St. Louis Cardinals
7 :  18
Boston Red Sox

Apr 6, 2025 - MLB

St. Louis Cardinals
4 :  5
Boston Red Sox

Apr 4, 2025 - MLB

St. Louis Cardinals
9 :  13
Boston Red Sox

Houston Astros against St. Louis Cardinals : Head to Head (H2H)

Houston Astros

67 %

St. Louis Cardinals

33 %

Apr 15, 2025 - MLB

Houston Astros
2 :  0
St. Louis Cardinals

Apr 14, 2025 - MLB

Houston Astros
3 :  8
St. Louis Cardinals

Mar 21, 2025 - MLB Spring Training

Houston Astros
5 :  3
St. Louis Cardinals

Mar 13, 2025 - MLB Spring Training

St. Louis Cardinals
1 :  1
Houston Astros

Mar 7, 2025 - MLB Spring Training

Houston Astros
4 :  6
St. Louis Cardinals

Mar 5, 2025 - MLB Spring Training

St. Louis Cardinals
5 :  6
Houston Astros

Houston Astros - St. Louis Cardinals Key Points

  1. Houston are 1-4 SU in their last 5 games against an opponent in the National League.
  2. Houston are 5-2 SU in their last 7 games when playing on the road against St. Louis.
  3. St. Louis are 2-5 SU in their last 7 games when playing at home against Houston.
  4. St. Louis are 1-4 SU in their last 5 games against an opponent in the American League.

Our Houston Astros vs St. Louis Cardinals Prediction

Houston are 5-2 SU in their last 7 games when playing on the road against St. Louis. However, I think the Cardinals will come out of the gates strong in Game 3 after a horrific game at the plate on Wednesday. There’s no way the Cardinals will be shut out for two days in a row, especially for a team that ranks first in batting average (.287) and third in total runs tally (90). The Cards have promoted relief pitcher Steven Matz as the starter on Wednesday. Although I am not expecting him to pitch beyond three innings, St. Louis would just be fine because their batting will deal heavy damage anyway against Astros starter Ronel Blanco, who has a 4.37 ERA in his last five starts. Our betting prediction for St. Louis Cardinals vs. Houston Astros: Cardinals will win.

Prediction:

 

Cardinals will win

+100
$1500 offered for betting!

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Houston Astros vs St. Louis Cardinals Picks