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Creighton vs Louisville Cardinals Prediction & Picks - NCAA Basketball
by Matt Lowrimore | in Basketball Picks
The first game of the NCAA tournament first round on Thursday will see the 9th-seeded Creighton Bluejays take on the 8th-seeded Louisville Cardinals in the South Region. Let’s take a look at the match statistics and predictions for this first-round game between the Bluejays and Cardinals to see who will advance to the Round of 32 over the weekend.
Creighton enters this game with a record of 24-10. They beat DePaul in the Big East quarterfinals, and UConn in the Big East semifinals before losing to St. John’s in the Big East final. Creighton will be making their 26th NCAA tournament appearance and their 5th consecutive appearance.
As for Louisville, they enter this game with a record of 27-7. The Cardinals beat Stanford in the ACC quarterfinals, Clemson in the ACC semifinals before losing to Duke in the ACC final. Louisville is making their 44th NCAA tournament appearance and their first appearance since the 2018-2019 season.
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Creighton vs Louisville Cardinals Form
Creighton and Louisville Cardinals Latest Matches

4/6 (67%)
2/6 (33%)
Mar 15, 2025 - NCAA Men
Mar 14, 2025 - NCAA Men
Mar 13, 2025 - NCAA Men
Mar 8, 2025 - NCAA Men
Mar 4, 2025 - NCAA Men
Mar 1, 2025 - NCAA Men
5/6 (83%)
1/6 (17%)
Mar 14, 2025 - NCAA Men
Mar 13, 2025 - NCAA Men
Mar 8, 2025 - NCAA Men
Feb 26, 2025 - NCAA Men
Feb 23, 2025 - NCAA Men
Feb 11, 2025 - NCAA Men
3/6 (50%)
3/6 (50%)
Mar 15, 2025 - NCAA Men
Mar 4, 2025 - NCAA Men
Mar 1, 2025 - NCAA Men
Feb 16, 2025 - NCAA Men
Feb 5, 2025 - NCAA Men
Feb 1, 2025 - NCAA Men

5/6 (83%)
1/6 (17%)
Mar 15, 2025 - NCAA Men
Mar 14, 2025 - NCAA Men
Mar 13, 2025 - NCAA Men
Mar 8, 2025 - NCAA Men
Mar 5, 2025 - NCAA Men
Mar 1, 2025 - NCAA Men
6/6 (100%)
0/6 (0%)
Mar 14, 2025 - NCAA Men
Mar 13, 2025 - NCAA Men
Mar 8, 2025 - NCAA Men
Mar 5, 2025 - NCAA Men
Mar 1, 2025 - NCAA Men
Feb 22, 2025 - NCAA Men
4/6 (67%)
2/6 (33%)
Mar 15, 2025 - NCAA Men
Feb 25, 2025 - NCAA Men
Feb 16, 2025 - NCAA Men
Feb 12, 2025 - NCAA Men
Feb 5, 2025 - NCAA Men
Feb 1, 2025 - NCAA Men
Creighton - Louisville Cardinals Key Points
- Louisville is 4-2 ATS in their last 6 games
- Louisville is 11-1 SU in their last 12 games
- Louisville is 5-1 SU in their last 6 March games
- Louisville is 10-0 SU in their last 10 games as a favorite
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Our Creighton vs Louisville Cardinals Prediction
There is something to be said about how much Louisville has improved since last season. The Cardinals were a miserable 8-24 in 2023-2024 and now have made the NCAA tournament with a chance to make a deep run. Louisville’s offense has improved significantly, averaging 79.1 points per game, which is top 60 in the country this season.
Creighton also has a top-tier offense but the difference is that they tend to be too reliant on the three-point shot. The Bluejays average nearly 28 three-point shots per game but shoot only about 34%. All it would take is for Creighton to have an off-day shooting and they may not have the inside or mid-range scoring to keep up. Because Creighton relies on the three-point shot too much, our Creighton Bluejays vs Louisville Cardinals prediction is Louisville ML.Grab an extra $200 for your Creighton vs Louisville Cardinals wager!
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