Cleveland Guardians vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
4/2/25 16:10
San Diego Padres

Prediction:

 

San Diego Padres will cover -1.5 runs

+135
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 by Lou Aguila | in MLB Picks

The San Diego head into Wednesday’s series finale with the Cleveland Guardians at Petco Park, looking to keep their immaculate record intact.

The Padres have put on an impeccable start to their 2025 MLB campaign with a scatheless 6-0 slate. San Diego possesses one of the most formidable batting lineups in baseball headed by Francisco Tatis Jr., Manny Machado and Jackson Merrill. However, the Padres have also imposed their will on the mound, where they posted a 1.80 ERA, 0.96 WHIP and .168 BAA – all in the top 5 in their respective categories.

The Guardians have no idea what hit them in the past two games. Cleveland entered the series with the Padres with a 2-1 record and had scored a total of 16 runs in the season-opening series against the Kansas City Royals. Against San Diego, the Guardians have only scored two runs so far and ended up scoreless 0-7 in Game 2.

Cleveland Guardians vs San Diego Padres Form

Table

Teams % P W L
1
San Diego Padres
San Diego Padres
1 7 7 0
19
Cleveland Guardians
Cleveland Guardians
0.333 6 2 4

Cleveland Guardians and San Diego Padres Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Cleveland Guardians
6 :  2
Kansas City Royals

Mar 29, 2025 - MLB

Cleveland Guardians
3 :  4
Kansas City Royals

Mar 27, 2025 - MLB

Cleveland Guardians
7 :  4
Kansas City Royals

Mar 25, 2025 - MLB Spring Training

Cleveland Guardians
3 :  2
Arizona Diamondbacks
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 19, 2025 - MLB Spring Training

Athletics
8 :  3
Cleveland Guardians

Mar 17, 2025 - MLB Spring Training

Cincinnati Reds
0 :  3
Cleveland Guardians

Mar 14, 2025 - MLB Spring Training

Seattle Mariners
7 :  8
Cleveland Guardians

Mar 12, 2025 - MLB Spring Training

San Francisco Giants
11 :  2
Cleveland Guardians

Mar 10, 2025 - MLB Spring Training

Chicago Cubs
7 :  4
Cleveland Guardians
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Cleveland Guardians
6 :  2
Kansas City Royals

Mar 29, 2025 - MLB

Cleveland Guardians
3 :  4
Kansas City Royals

Mar 27, 2025 - MLB

Cleveland Guardians
7 :  4
Kansas City Royals

Mar 25, 2025 - MLB Spring Training

Cleveland Guardians
3 :  2
Arizona Diamondbacks
San Diego Padres
San Diego Padres Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres

Mar 27, 2025 - MLB

Atlanta Braves
4 :  7
San Diego Padres
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres

Mar 27, 2025 - MLB

Atlanta Braves
4 :  7
San Diego Padres
W W L W L D
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 23, 2025 - MLB Spring Training

San Diego Padres
5 :  5
Arizona Diamondbacks

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

Mar 16, 2025 - MLB Spring Training

San Diego Padres
4 :  2
Los Angeles Angels

Mar 15, 2025 - MLB Spring Training

San Diego Padres
8 :  3
Seattle Mariners

Cleveland Guardians against San Diego Padres : Head to Head (H2H)

Cleveland Guardians

17 %

San Diego Padres

83 %

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 8, 2025 - MLB Spring Training

Cleveland Guardians
2 :  7
San Diego Padres

Jul 21, 2024 - MLB

San Diego Padres
2 :  1
Cleveland Guardians

Jul 20, 2024 - MLB

San Diego Padres
7 :  0
Cleveland Guardians

Cleveland Guardians - San Diego Padres Key Points

  1. San Diego are 5-0 SU in their last 5 games at home.
  2. San Diego are 4-1 SU in their last 5 games when playing at home against Cleveland.
  3. Cleveland are 2-5 SU in their last 7 games.
  4. Cleveland are 1-4 SU in their last 5 games against San Diego.

Our Cleveland Guardians vs San Diego Padres Prediction

The Padres are sending Dylan Cease to the mound on Wednesday. Cease is 2-1 in his last three faceoffs with the Guardians, whom he blanked for seven innings with 10 strikeouts in San Diego’s 7-0 win last July 20, 2024. He will duel against Edward Lively, who is 4-1 in his last five starts but allowed two earned runs in a 1-2 loss to San Diego on July 21. In what will likely be a low-scoring match, I still expect the Padres to grind out a close win behind their terrific bullpen that has only allowed a 0.38 ERA this season. San Diego has also been superior at home with a 5-0 record, covering the spread four times. Our betting prediction for San Diego Padres vs. Cleveland Guardians: Padres will cover -1.5 runs.

Prediction:

 

San Diego Padres will cover -1.5 runs

+135
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Cleveland Guardians vs San Diego Padres Picks