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by Lou Aguila in MLB Picks
The San Diego head into Wednesday’s series finale with the Cleveland Guardians at Petco Park, looking to keep their immaculate record intact.
The Padres have put on an impeccable start to their 2025 MLB campaign with a scatheless 6-0 slate. San Diego possesses one of the most formidable batting lineups in baseball headed by Francisco Tatis Jr., Manny Machado and Jackson Merrill. However, the Padres have also imposed their will on the mound, where they posted a 1.80 ERA, 0.96 WHIP and .168 BAA – all in the top 5 in their respective categories.
The Guardians have no idea what hit them in the past two games. Cleveland entered the series with the Padres with a 2-1 record and had scored a total of 16 runs in the season-opening series against the Kansas City Royals. Against San Diego, the Guardians have only scored two runs so far and ended up scoreless 0-7 in Game 2.
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Cleveland Guardians vs San Diego Padres Form
Table
| Teams | % | P | W | L |
|---|---|---|---|---|
|
2
|
0.68 | 25 | 17 | 8 |
|
8
|
0.583 | 24 | 14 | 10 |
Cleveland Guardians and San Diego Padres Latest Matches
3/6 (50%)
3/6 (50%)
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
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Mar 25, 2025 - MLB Spring Training
3/6 (50%)
3/6 (50%)
Mar 22, 2025 - MLB Spring Training
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3/6 (50%)
3/6 (50%)
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
Mar 30, 2025 - MLB
Mar 29, 2025 - MLB
Mar 27, 2025 - MLB
Mar 25, 2025 - MLB Spring Training
6/6 (100%)
0/6 (0%)
Apr 1, 2025 - MLB
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Mar 27, 2025 - MLB
6/6 (100%)
0/6 (0%)
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
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Mar 27, 2025 - MLB
3/6 (50%)
3/6 (50%)
Mar 23, 2025 - MLB Spring Training
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Mar 18, 2025 - MLB Spring Training
Mar 16, 2025 - MLB Spring Training
Mar 15, 2025 - MLB Spring Training
Cleveland Guardians against San Diego Padres : Head to Head (H2H)
17 %
83 %
Apr 1, 2025 - MLB
Mar 31, 2025 - MLB
Mar 22, 2025 - MLB Spring Training
Mar 8, 2025 - MLB Spring Training
Jul 21, 2024 - MLB
Jul 20, 2024 - MLB
Cleveland Guardians - San Diego Padres Key Points
- San Diego are 5-0 SU in their last 5 games at home.
- San Diego are 4-1 SU in their last 5 games when playing at home against Cleveland.
- Cleveland are 2-5 SU in their last 7 games.
- Cleveland are 1-4 SU in their last 5 games against San Diego.
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Our Cleveland Guardians vs San Diego Padres Prediction
The Padres are sending Dylan Cease to the mound on Wednesday. Cease is 2-1 in his last three faceoffs with the Guardians, whom he blanked for seven innings with 10 strikeouts in San Diego’s 7-0 win last July 20, 2024. He will duel against Edward Lively, who is 4-1 in his last five starts but allowed two earned runs in a 1-2 loss to San Diego on July 21. In what will likely be a low-scoring match, I still expect the Padres to grind out a close win behind their terrific bullpen that has only allowed a 0.38 ERA this season. San Diego has also been superior at home with a 5-0 record, covering the spread four times. Our betting prediction for San Diego Padres vs. Cleveland Guardians: Padres will cover -1.5 runs.
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