Cleveland Guardians vs San Diego Padres Prediction & Picks - MLB

See our betting tips for the next match between these two teams
Cleveland Guardians - San Diego Padres Betting tips

USA - MLB

Cleveland Guardians
3/31/25 20:40
San Diego Padres

Prediction:

 

Padres ML.

-131
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Carlos Zabala | in MLB Picks

In 2024, the Padres' record at Petco Park was 48-36, and in the 2025 season, they swept the Braves, blanking them 5-0 in the final game of the series with a spectacular 7-inning outing by Pivetta, where he allowed only one hit and struck out four. In that victory, Manny Machado, along with Bogaerts and Merill, had an RBI double, and Tatis Jr. drove in the last run of the game for the Padres, who managed nine hits on Sunday night.

Now, back at Petco Park, the Padres are preparing to host another tough team in the Cleveland Guardians, who won their division last season and already won their first series of 2025 against the Royals in Kansas City. The Guardians finished last in the series with a 6-2 victory. Stephen Vogt's team was without superstar Ramírez for the decisive game, but 24-year-old Kyle Manzardo has taken over the Guardians' offense, going 3-for-6 with 4 RBIs in an encouraging start to the season.

In 2024, the Padres won the series against the Guardians in Cleveland 2-1. The scheduled pitchers for Monday's game are Ortiz for the Guardians and Hart for the Padres.

Cleveland Guardians vs San Diego Padres Form

Table

Teams % P W L
1
San Diego Padres
San Diego Padres
1 5 5 0
13
Cleveland Guardians
Cleveland Guardians
0.5 4 2 2

Cleveland Guardians and San Diego Padres Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 30, 2025 - MLB

Cleveland Guardians
6 :  2
Kansas City Royals

Mar 29, 2025 - MLB

Cleveland Guardians
3 :  4
Kansas City Royals

Mar 27, 2025 - MLB

Cleveland Guardians
7 :  4
Kansas City Royals

Mar 25, 2025 - MLB Spring Training

Cleveland Guardians
3 :  2
Arizona Diamondbacks

Mar 24, 2025 - MLB Spring Training

Cleveland Guardians
4 :  3
Arizona Diamondbacks

Mar 23, 2025 - MLB Spring Training

Cleveland Guardians
2 :  13
Cincinnati Reds
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 19, 2025 - MLB Spring Training

Athletics
8 :  3
Cleveland Guardians

Mar 17, 2025 - MLB Spring Training

Cincinnati Reds
0 :  3
Cleveland Guardians

Mar 14, 2025 - MLB Spring Training

Seattle Mariners
7 :  8
Cleveland Guardians

Mar 12, 2025 - MLB Spring Training

San Francisco Giants
11 :  2
Cleveland Guardians

Mar 10, 2025 - MLB Spring Training

Chicago Cubs
7 :  4
Cleveland Guardians
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 30, 2025 - MLB

Cleveland Guardians
6 :  2
Kansas City Royals

Mar 29, 2025 - MLB

Cleveland Guardians
3 :  4
Kansas City Royals

Mar 27, 2025 - MLB

Cleveland Guardians
7 :  4
Kansas City Royals

Mar 25, 2025 - MLB Spring Training

Cleveland Guardians
3 :  2
Arizona Diamondbacks

Mar 24, 2025 - MLB Spring Training

Cleveland Guardians
4 :  3
Arizona Diamondbacks

Mar 23, 2025 - MLB Spring Training

Cleveland Guardians
2 :  13
Cincinnati Reds
San Diego Padres
San Diego Padres Latest matches
D D W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres

Mar 27, 2025 - MLB

Atlanta Braves
4 :  7
San Diego Padres

Mar 24, 2025 - MLB Spring Training

Seattle Mariners
7 :  7
San Diego Padres

Mar 23, 2025 - MLB Spring Training

San Diego Padres
5 :  5
Arizona Diamondbacks
W D W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Mar 30, 2025 - MLB

Atlanta Braves
0 :  5
San Diego Padres

Mar 29, 2025 - MLB

Atlanta Braves
0 :  1
San Diego Padres

Mar 28, 2025 - MLB

Atlanta Braves
3 :  4
San Diego Padres

Mar 27, 2025 - MLB

Atlanta Braves
4 :  7
San Diego Padres

Mar 24, 2025 - MLB Spring Training

Seattle Mariners
7 :  7
San Diego Padres

Mar 22, 2025 - MLB Spring Training

Cincinnati Reds
0 :  1
San Diego Padres
W W L W L D
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 23, 2025 - MLB Spring Training

San Diego Padres
5 :  5
Arizona Diamondbacks

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

Mar 16, 2025 - MLB Spring Training

San Diego Padres
4 :  2
Los Angeles Angels

Mar 15, 2025 - MLB Spring Training

San Diego Padres
8 :  3
Seattle Mariners

Cleveland Guardians against San Diego Padres : Head to Head (H2H)

Cleveland Guardians

50 %

San Diego Padres

50 %

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 8, 2025 - MLB Spring Training

Cleveland Guardians
2 :  7
San Diego Padres

Jul 21, 2024 - MLB

San Diego Padres
2 :  1
Cleveland Guardians

Jul 20, 2024 - MLB

San Diego Padres
7 :  0
Cleveland Guardians

Jul 19, 2024 - MLB

San Diego Padres
0 :  7
Cleveland Guardians

Aug 24, 2022 - MLB

Cleveland Guardians
7 :  0
San Diego Padres

Cleveland Guardians - San Diego Padres Key Points

  1. Guardians have yet to steal their first base from 2025
  2. Padres had a total of 18 walks in their last game against the Braves
  3. Seven of the Guardians' last 10 games have resulted in a total of OVER
  4. Guardians hit five home runs in the opening series against the Royals

Our Cleveland Guardians vs San Diego Padres Prediction

Ortiz was acquired from the Pirates by the Guardians to complete their rotation this season. In 2024, Ortiz faced the Padres twice, and on both occasions his team lost, allowing two or more earned runs. A bettor who placed $100 on the Padres' ML this season would have accumulated a total of +$397 with the four wins. Once again, the Padres ML looks attractive. Our prediction for Padres vs Guardians is: Padres ML.

Prediction:

 

Padres ML.

-131
$200 offered for betting!

Grab an extra $200 for your Cleveland Guardians vs San Diego Padres wager!

FD Bet $5, Get $200

Get ready to experience the thrill of the game with FanDuel's exciting welcome offer, available for use on the Cleveland Guardians vs San Diego Padres matchup!

A minimum bet of $5 will qualify for $200 in bonus bets if your bet wins! This offer is a golden opportunity for new users. Don't miss out on this limited-time deal to enhance your sports betting experience with some extra oomph! Jump into the action today and let FanDuel take your sports engagement to the next level!

$200 available for Cleveland Guardians vs San Diego Padres

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Cleveland Guardians vs San Diego Padres Picks