Cincinnati Reds vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

Cincinnati Reds
4/7/25 21:45
San Francisco Giants

Prediction:

 

UNDER 7

-122
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 by Travis Pulver in MLB Picks

The Cincinnati Reds will try to get things turned around as they head to San Francisco for a three-game series vs. the Giants. Game One is scheduled to get underway tonight at 9:45 p.m. EST.

It has certainly been a struggle for the Reds so far this season. They have managed to win one in each series (they’ve played three), and that’s it. After making history with three consecutive 1-0 losses, they lost a fourth straight game but scored two runs (3-2). Their bats finally woke up against the Brewers on Saturday for 14 hits and 11 runs, but then it came crashing back down to Earth in the series finale Sunday in an 8-2 loss. San Francisco’s only loss of the season came in their season-opening series vs. the Reds in Cincinnati (Game Two, 3-2). They have since gone 7-0 and sit in first place in the NL West, a game above the LA Dodgers.

The Reds will give the ball to Hunter Greene tonight. He started the season opener against the Giants, lasting five innings and giving up three hits, including a home run, and two runs while striking out eight. Greene was also the pitcher for one of the 1-0 losses (vs. Texas, seven innings, three hits, one run, eight strikeouts). San Francisco is going with Logan Webb, who started the season opener vs. Greene but didn’t factor into the decision.

Cincinnati Reds vs San Francisco Giants Form

Table

Teams % P W L
2
San Francisco Giants
San Francisco Giants
0.643 28 18 10
11
Cincinnati Reds
Cincinnati Reds
0.519 27 14 13

Cincinnati Reds and San Francisco Giants Latest Matches

Cincinnati Reds
Cincinnati Reds Latest matches
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 6, 2025 - MLB

Cincinnati Reds
2 :  8
Milwaukee Brewers

Apr 5, 2025 - MLB

Cincinnati Reds
11 :  7
Milwaukee Brewers

Apr 4, 2025 - MLB

Cincinnati Reds
2 :  3
Milwaukee Brewers

Apr 3, 2025 - MLB

Cincinnati Reds
0 :  1
Milwaukee Brewers

Apr 2, 2025 - MLB

Texas Rangers
1 :  0
Cincinnati Reds

Apr 1, 2025 - MLB

Texas Rangers
1 :  0
Cincinnati Reds
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 2, 2025 - MLB

Texas Rangers
1 :  0
Cincinnati Reds

Apr 1, 2025 - MLB

Texas Rangers
1 :  0
Cincinnati Reds

Mar 31, 2025 - MLB

Texas Rangers
3 :  14
Cincinnati Reds

Mar 30, 2025 - MLB

San Francisco Giants
6 :  3
Cincinnati Reds

Mar 29, 2025 - MLB

San Francisco Giants
2 :  3
Cincinnati Reds

Mar 27, 2025 - MLB

San Francisco Giants
6 :  4
Cincinnati Reds
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 6, 2025 - MLB

Cincinnati Reds
2 :  8
Milwaukee Brewers

Apr 5, 2025 - MLB

Cincinnati Reds
11 :  7
Milwaukee Brewers

Apr 4, 2025 - MLB

Cincinnati Reds
2 :  3
Milwaukee Brewers

Apr 3, 2025 - MLB

Cincinnati Reds
0 :  1
Milwaukee Brewers

Mar 22, 2025 - MLB Spring Training

Cincinnati Reds
0 :  1
San Diego Padres

Mar 21, 2025 - MLB Spring Training

Cincinnati Reds
5 :  3
Seattle Mariners
San Francisco Giants
San Francisco Giants Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 6, 2025 - MLB

Seattle Mariners
4 :  5
San Francisco Giants

Apr 5, 2025 - MLB

Seattle Mariners
1 :  4
San Francisco Giants

Apr 4, 2025 - MLB

Seattle Mariners
9 :  10
San Francisco Giants

Apr 2, 2025 - MLB

San Francisco Giants
6 :  3
Houston Astros

Apr 1, 2025 - MLB

San Francisco Giants
3 :  1
Houston Astros

Mar 31, 2025 - MLB

San Francisco Giants
7 :  2
Houston Astros
D W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 6, 2025 - MLB

Seattle Mariners
4 :  5
San Francisco Giants

Apr 5, 2025 - MLB

Seattle Mariners
1 :  4
San Francisco Giants

Apr 4, 2025 - MLB

Seattle Mariners
9 :  10
San Francisco Giants

Mar 25, 2025 - MLB Spring Training

Detroit Tigers
3 :  4
San Francisco Giants

Mar 24, 2025 - MLB Spring Training

Detroit Tigers
4 :  6
San Francisco Giants

Mar 22, 2025 - MLB Spring Training

Arizona Diamondbacks
7 :  7
San Francisco Giants
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 2, 2025 - MLB

San Francisco Giants
6 :  3
Houston Astros

Apr 1, 2025 - MLB

San Francisco Giants
3 :  1
Houston Astros

Mar 31, 2025 - MLB

San Francisco Giants
7 :  2
Houston Astros

Mar 30, 2025 - MLB

San Francisco Giants
6 :  3
Cincinnati Reds

Mar 29, 2025 - MLB

San Francisco Giants
2 :  3
Cincinnati Reds

Mar 27, 2025 - MLB

San Francisco Giants
6 :  4
Cincinnati Reds

Cincinnati Reds against San Francisco Giants : Head to Head (H2H)

Cincinnati Reds

17 %

San Francisco Giants

83 %

Mar 30, 2025 - MLB

San Francisco Giants
6 :  3
Cincinnati Reds

Mar 29, 2025 - MLB

San Francisco Giants
2 :  3
Cincinnati Reds

Mar 27, 2025 - MLB

San Francisco Giants
6 :  4
Cincinnati Reds

Feb 23, 2025 - MLB Spring Training

Cincinnati Reds
2 :  5
San Francisco Giants

Aug 4, 2024 - MLB

San Francisco Giants
8 :  2
Cincinnati Reds

Aug 2, 2024 - MLB

San Francisco Giants
3 :  0
Cincinnati Reds

Cincinnati Reds - San Francisco Giants Key Points

  1. The Giants are off to an 8-1, 3-0 at home start while the Reds are 3-7, 1-3 away.
  2. San Francisco leads the all-time series vs. Cincinnati 1239-1036-15.
  3. Cincinnati went 1-2 at home and on the road vs. San Francisco last season.
  4. 95% of the moneyline tickets and 99% of the handle is on San Francisco.

Our Cincinnati Reds vs San Francisco Giants Prediction

When these two pitched in the opener, the teams scored ten runs. But since then, the Reds' lineup has struggled to make contact. San Francisco has been hitting well this season, but Greene did a great job against them in the opener. I’m betting the Reds' bats will go silent again, but Greene will keep the Giants in check. The easy bet here is the Giants ML, but I’m going with something else.

Our Reds vs. Giants Pick: UNDER 7

Prediction:

 

UNDER 7

-122
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Cincinnati Reds vs San Francisco Giants Picks