Chicago White Sox vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

Chicago White Sox
4/22/25 19:40
Minnesota Twins

Prediction:

 

Under 8.5

-105
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 by Erik Gibbs | in MLB Picks

The Chicago White Sox and Minnesota Twins kick off a three-game series on Tuesday in what's shaping up to be a basement battle in the AL Central. Neither team has found its footing early in the 2025 season, with the White Sox sitting at the very bottom of the division with a 5-17 record, while the Twins haven't fared much better at 7-14, just one spot ahead.

Chicago enters this series fresh off a 4-2 loss on the road to the Boston Red Sox on Monday, continuing what has been a rough stretch for a team that simply hasn't found consistency on either side of the ball. Meanwhile, the Twins are also licking their wounds after being swept by the Atlanta Braves over the weekend.

It was a disappointing outcome considering Atlanta has struggled themselves in the early going. In Sunday's finale, Minnesota briefly showed life with a seventh-inning homer from Byron Buxton, but ultimately fell short, losing 6-2.

Chicago White Sox vs Minnesota Twins Form

Table

Teams % P W L
28
Minnesota Twins
Minnesota Twins
0.318 22 7 15
29
Chicago White Sox
Chicago White Sox
0.227 22 5 17

Chicago White Sox and Minnesota Twins Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 21, 2025 - MLB

Chicago White Sox
2 :  4
Boston Red Sox

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 17, 2025 - MLB

Athletics
8 :  0
Chicago White Sox

Apr 16, 2025 - MLB

Athletics
3 :  1
Chicago White Sox
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 17, 2025 - MLB

Athletics
8 :  0
Chicago White Sox

Apr 16, 2025 - MLB

Athletics
3 :  1
Chicago White Sox

Apr 15, 2025 - MLB

Athletics
12 :  3
Chicago White Sox

Apr 13, 2025 - MLB

Boston Red Sox
3 :  1
Chicago White Sox

Apr 12, 2025 - MLB

Boston Red Sox
2 :  3
Chicago White Sox

Apr 11, 2025 - MLB

Boston Red Sox
1 :  11
Chicago White Sox
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 21, 2025 - MLB

Chicago White Sox
2 :  4
Boston Red Sox

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 10, 2025 - MLB

Chicago White Sox
1 :  6
Cleveland Guardians

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians
Minnesota Twins
Minnesota Twins Latest matches
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 20, 2025 - MLB

Minnesota Twins
2 :  6
Atlanta Braves

Apr 19, 2025 - MLB

Minnesota Twins
3 :  4
Atlanta Braves

Apr 18, 2025 - MLB

Minnesota Twins
4 :  6
Atlanta Braves

Apr 16, 2025 - MLB

New York Mets
3 :  4
Minnesota Twins

Apr 15, 2025 - MLB

New York Mets
3 :  6
Minnesota Twins

Apr 14, 2025 - MLB

New York Mets
5 :  1
Minnesota Twins
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

New York Mets
3 :  4
Minnesota Twins

Apr 15, 2025 - MLB

New York Mets
3 :  6
Minnesota Twins

Apr 14, 2025 - MLB

New York Mets
5 :  1
Minnesota Twins

Apr 13, 2025 - MLB

Detroit Tigers
1 :  5
Minnesota Twins

Apr 12, 2025 - MLB

Detroit Tigers
4 :  0
Minnesota Twins

Apr 11, 2025 - MLB

Detroit Tigers
7 :  6
Minnesota Twins
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 20, 2025 - MLB

Minnesota Twins
2 :  6
Atlanta Braves

Apr 19, 2025 - MLB

Minnesota Twins
3 :  4
Atlanta Braves

Apr 18, 2025 - MLB

Minnesota Twins
4 :  6
Atlanta Braves

Apr 10, 2025 - MLB

Minnesota Twins
2 :  3
Kansas City Royals

Apr 9, 2025 - MLB

Minnesota Twins
4 :  0
Kansas City Royals

Apr 8, 2025 - MLB

Minnesota Twins
1 :  2
Kansas City Royals

Chicago White Sox against Minnesota Twins : Head to Head (H2H)

Chicago White Sox

17 %

Minnesota Twins

83 %

Apr 2, 2025 - MLB

Minnesota Twins
6 :  1
Chicago White Sox

Apr 1, 2025 - MLB

Minnesota Twins
8 :  3
Chicago White Sox

Mar 31, 2025 - MLB

Minnesota Twins
0 :  9
Chicago White Sox

Aug 4, 2024 - MLB

Chicago White Sox
7 :  13
Minnesota Twins

Aug 3, 2024 - MLB

Chicago White Sox
2 :  6
Minnesota Twins

Aug 2, 2024 - MLB

Chicago White Sox
2 :  10
Minnesota Twins

Chicago White Sox - Minnesota Twins Key Points

  1. The White Sox are 11-11 ATS this season
  2. The Twins are 9-13 ATS this season
  3. The White Sox are 8-0 covering the run line in last 8 Tuesday night games when road underdogs vs. AL Central teams
  4. The underdogs are 10-3 in the last 13 Twins games at Target Field

Our Chicago White Sox vs Minnesota Twins Prediction

Tuesday's series opener features a pitching matchup between two right-handers in Bailey Ober for Minnesota and Davis Martin for Chicago. Neither has lit the world on fire this season, but Martin has been marginally more reliable. Ober, 29, comes in with a 6.16 ERA over four starts, allowing five home runs and a total of 13 earned runs across those appearances. His control has been decent—17 strikeouts against six walks—but the long ball has been a persistent issue. He's coming off one of his better starts, however, having tossed 6.1 innings and giving up just three earned runs in a win over the Mets.

Davis Martin, on the other hand, has posted a 4.84 ERA through four outings, with 13 strikeouts and the same number of walks as Ober. While not dominant, he's been serviceable, and his numbers suggest slightly better command and damage control. In his most recent start, Martin went 5.1 innings and gave up four earned runs in a loss to the Oakland Athletics.

Though both teams have struggled, the matchup is closer than the records suggest. The Twins may have a slight edge on paper, but with Ober's inconsistency and tendency to give up home runs, the White Sox have a real chance to open this series with a competitive showing. Chicago might not be a powerhouse, but they're not massively outmatched either—and if Martin can keep things under control, the White Sox could steal one here. Our prediction for the Minnesota Twins vs. Chicago White Sox: White Sox to win.

Prediction:

 

Under 8.5

-105
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Chicago White Sox vs Minnesota Twins Picks