Chicago White Sox vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Chicago White Sox
4/10/25 13:10
Cleveland Guardians

Prediction:

 

Guardians will cover -1.5 Runs

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 by Lou Aguila | in MLB Picks

The Cleveland Guardians marched into Progressive Field on Thursday, aiming for a three-game sweep of the Chicago White Sox.

The Guardians have won three of their last five games, including two straight at the expense of the White Sox. Cleveland demonstrated impeccable pitching in the last two games, limiting Chicago to a total of three runs across 18 innings. Cleveland, who is pitching a 3.98 ERA in their last five games, will be dispatching Garvin Williams (1-4, 4.29 in last five start).

The White Sox have lost their last seven games after a 2-2 start. Chicago isn’t pitching that bad in the series, as they have hounded the Guardians to just four runs between Game 1 and 2, but their offense has been flat-out dreadful. In their last five games, Chicago has averaged 2.2 runs per game on a .190 batting average.

Chicago White Sox vs Cleveland Guardians Form

Table

Teams % P W L
8
Cleveland Guardians
Cleveland Guardians
0.583 24 14 10
29
Chicago White Sox
Chicago White Sox
0.24 25 6 19

Chicago White Sox and Cleveland Guardians Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Apr 6, 2025 - MLB

Chicago White Sox
3 :  4
Detroit Tigers

Apr 5, 2025 - MLB

Chicago White Sox
2 :  7
Detroit Tigers

Apr 4, 2025 - MLB

Chicago White Sox
4 :  7
Detroit Tigers

Apr 2, 2025 - MLB

Minnesota Twins
6 :  1
Chicago White Sox
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 2, 2025 - MLB

Minnesota Twins
6 :  1
Chicago White Sox

Apr 1, 2025 - MLB

Minnesota Twins
8 :  3
Chicago White Sox

Mar 31, 2025 - MLB

Minnesota Twins
0 :  9
Chicago White Sox

Mar 30, 2025 - MLB

Los Angeles Angels
3 :  2
Chicago White Sox

Mar 29, 2025 - MLB

Los Angeles Angels
1 :  0
Chicago White Sox

Mar 27, 2025 - MLB

Los Angeles Angels
1 :  8
Chicago White Sox
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Apr 6, 2025 - MLB

Chicago White Sox
3 :  4
Detroit Tigers

Apr 5, 2025 - MLB

Chicago White Sox
2 :  7
Detroit Tigers

Apr 4, 2025 - MLB

Chicago White Sox
4 :  7
Detroit Tigers

Mar 22, 2025 - MLB Spring Training

Chicago White Sox
4 :  10
Colorado Rockies
Cleveland Guardians
Cleveland Guardians Latest matches
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Apr 6, 2025 - MLB

Cleveland Guardians
2 :  6
Los Angeles Angels

Apr 5, 2025 - MLB

Cleveland Guardians
4 :  10
Los Angeles Angels

Apr 4, 2025 - MLB

Cleveland Guardians
8 :  6
Los Angeles Angels

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 19, 2025 - MLB Spring Training

Athletics
8 :  3
Cleveland Guardians

Mar 17, 2025 - MLB Spring Training

Cincinnati Reds
0 :  3
Cleveland Guardians

Mar 14, 2025 - MLB Spring Training

Seattle Mariners
7 :  8
Cleveland Guardians
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 6, 2025 - MLB

Cleveland Guardians
2 :  6
Los Angeles Angels

Apr 5, 2025 - MLB

Cleveland Guardians
4 :  10
Los Angeles Angels

Apr 4, 2025 - MLB

Cleveland Guardians
8 :  6
Los Angeles Angels

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Chicago White Sox against Cleveland Guardians : Head to Head (H2H)

Chicago White Sox

17 %

Cleveland Guardians

83 %

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Mar 9, 2025 - MLB Spring Training

Chicago White Sox
0 :  1
Cleveland Guardians

Feb 27, 2025 - MLB Spring Training

Cleveland Guardians
2 :  4
Chicago White Sox

Sep 11, 2024 - MLB

Cleveland Guardians
6 :  4
Chicago White Sox

Sep 10, 2024 - MLB

Cleveland Guardians
5 :  0
Chicago White Sox

Chicago White Sox - Cleveland Guardians Key Points

  1. Chicago White Sox are 0-6 SU in their last 6 games against Cleveland.
  2. Chicago White Sox are 0-7 SU in their last 7 games.
  3. Cleveland are 5-1 SU in their last 6 games when playing at home against Chicago White Sox.
  4. Cleveland are 4-2 SU in their last 6 games against an opponent in the American League.

Our Chicago White Sox vs Cleveland Guardians Prediction

The White Sox got a serviceable pitcher for Game 3 in Jonathan Cannon, who is 2-3 with a 3.76 ERA in his last five starts. Cannon allowed three runs in his last starts vs. the Tigers (4-7 loss) but had blanked the LA Angels in 5.0 innings in his season debut last March 29. Cannon is a solid pitcher, but I am unsure if he can carry Chicago to a win in Game 3 because they are disappointing on offense.

The Guardians have won their last six meetings for multiple reasons. And that same set of reasons will guide Cleveland to their most convincing series win over the hapless White Sox. Our betting prediction for Chicago White Sox vs. Cleveland Guardians: Cleveland Guardians will cover -1.5 Runs.

Prediction:

 

Guardians will cover -1.5 Runs

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Chicago White Sox vs Cleveland Guardians Picks