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Chicago White Sox vs Boston Red Sox Prediction & Picks - MLB

USA - MLB

Chicago White Sox
4/21/25 10:10
Boston Red Sox

Prediction:

 

Red Sox -1.5 Runs

-130
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 by Lou Aguila in MLB Picks

The Boston Red Sox will head into Monday’s matinee game against the Chicago White Sox, looking to win three out of four games in the series at Fenway Park.

The Red Sox have gained a bit of steam as of late, winning four of their last five games. Sunday’s 4-8 loss to the White Sox snapped their four-game winning streak, but Boston has nevertheless improved their hitting numbers over the weekend, raising their batting average to .246 with 104 runs this season.

The White Sox pulled off a come-from-behind win on Sunday after Brooks Baldwin’s sacrifice hit ignited four unanswered runs between the 7th and 9th inning to erase a 2-4 deficit. The White Sox earned only their fifth win of the year, but hope the comeback win would wake up their spirit and start competing for wins.

Chicago White Sox vs Boston Red Sox Form

Table

Teams % P W L
14
Boston Red Sox
Boston Red Sox
0.519 27 14 13
29
Chicago White Sox
Chicago White Sox
0.24 25 6 19

Chicago White Sox and Boston Red Sox Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 17, 2025 - MLB

Athletics
8 :  0
Chicago White Sox

Apr 16, 2025 - MLB

Athletics
3 :  1
Chicago White Sox

Apr 15, 2025 - MLB

Athletics
12 :  3
Chicago White Sox
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 17, 2025 - MLB

Athletics
8 :  0
Chicago White Sox

Apr 16, 2025 - MLB

Athletics
3 :  1
Chicago White Sox

Apr 15, 2025 - MLB

Athletics
12 :  3
Chicago White Sox

Apr 13, 2025 - MLB

Boston Red Sox
3 :  1
Chicago White Sox

Apr 12, 2025 - MLB

Boston Red Sox
2 :  3
Chicago White Sox

Apr 11, 2025 - MLB

Boston Red Sox
1 :  11
Chicago White Sox
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 10, 2025 - MLB

Chicago White Sox
1 :  6
Cleveland Guardians

Apr 9, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians
Boston Red Sox
Boston Red Sox Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 16, 2025 - MLB

Boston Red Sox
1 :  0
Tampa Bay Rays

Apr 15, 2025 - MLB

Boston Red Sox
7 :  4
Tampa Bay Rays

Apr 14, 2025 - MLB

Boston Red Sox
1 :  16
Tampa Bay Rays
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 10, 2025 - MLB

Toronto Blue Jays
3 :  4
Boston Red Sox

Apr 9, 2025 - MLB

Toronto Blue Jays
2 :  1
Boston Red Sox

Apr 8, 2025 - MLB

Toronto Blue Jays
6 :  1
Boston Red Sox
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

Boston Red Sox
1 :  0
Tampa Bay Rays

Apr 15, 2025 - MLB

Boston Red Sox
7 :  4
Tampa Bay Rays

Apr 14, 2025 - MLB

Boston Red Sox
1 :  16
Tampa Bay Rays

Apr 13, 2025 - MLB

Boston Red Sox
3 :  1
Chicago White Sox

Apr 12, 2025 - MLB

Boston Red Sox
2 :  3
Chicago White Sox

Apr 11, 2025 - MLB

Boston Red Sox
1 :  11
Chicago White Sox

Chicago White Sox against Boston Red Sox : Head to Head (H2H)

Chicago White Sox

50 %

Boston Red Sox

50 %

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox

Apr 18, 2025 - MLB

Chicago White Sox
3 :  10
Boston Red Sox

Apr 13, 2025 - MLB

Boston Red Sox
3 :  1
Chicago White Sox

Apr 12, 2025 - MLB

Boston Red Sox
2 :  3
Chicago White Sox

Apr 11, 2025 - MLB

Boston Red Sox
1 :  11
Chicago White Sox

Chicago White Sox - Boston Red Sox Key Points

  1. Boston is 4-1 SU in its last 5 games.
  2. Boston is 5-2 SU in its last 7 games against an opponent in the American League.
  3. Chicago White Sox is 1-6 SU in its last 7 games.
  4. Chicago White Sox is 1-8 SU in its last 9 games on the road.

Our Chicago White Sox vs Boston Red Sox Prediction

Fearless Forecast: the Red Sox will bounce back in a big way, securing both the series and against the spread win.

The Red Sox will start Walker Buehler (2-1, 5.23 ERA) to close out the series against the White Sox with a bang. Despite the not-so-impressive ERA, Buehler has put the Red Sox in a position to win this season, especially in his last two starts, where he has allowed only three earned runs. White Sox’s starter Jonathan Cannon is fresh off a 4.1-inning shutout of the Oakland Athletics. But like what happened in that game, Cannon will probably get another L again because he can’t get enough run support from the White Sox sluggers. Boston is 4-1 SU in its last 5 games. Our betting prediction for Chicago White Sox vs. Boston Red Sox: Red Sox will cover -1.5 runs.

Prediction:

 

Red Sox -1.5 Runs

-130
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Chicago White Sox vs Boston Red Sox Picks