Chicago Cubs vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Chicago Cubs
4/16/25 16:10
San Diego Padres

Prediction:

 

UNDER 7.5

-105
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 by Travis Pulver in MLB Picks

The Chicago Cubs will take on the NL West-leading Padres in Game Three of a three-game series today at Petco Park in San Diego, CA. Fans can follow the action on Padres.TV when the game gets underway at 4:10 p.m. EST.

It’s been a good road trip for the Cubs. They took two of three against the Dodgers in LA over the weekend and evened up their current series vs. the Padres with a 2-1 victory in ten innings last night. Both starting pitchers had solid five-inning outings, with each team scoring one run. Each team’s bullpen pitched well, but then Nico Hoerner’s triple in the top of the tenth got the winning run across the plate and secured the win for the visiting Cubs.

The Cubs will turn to lefty Matthew Boyd to start the game today. He’s had a pretty good start to the season, holding opponents scoreless in his first two outings. Boyd (1-1) got the win vs. the Padres in Chicago in his second outing 7-1 but lost his last time out after giving up three runs to the Dodgers. It will be Nick Pivetta for the Padres. Pivetta (2-1) started vs. the Cubs in Chicago in the game Boyd ultimately won. While he only lasted three innings in that game, he threw seven scoreless innings in his other two (both shutout wins).

Chicago Cubs vs San Diego Padres Form

Table

Teams % P W L
2
San Diego Padres
San Diego Padres
0.68 25 17 8
5
Chicago Cubs
Chicago Cubs
0.615 26 16 10

Chicago Cubs and San Diego Padres Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Chicago Cubs
4 :  2
Los Angeles Dodgers

Apr 12, 2025 - MLB

Chicago Cubs
16 :  0
Los Angeles Dodgers

Apr 11, 2025 - MLB

Chicago Cubs
0 :  3
Los Angeles Dodgers

Apr 9, 2025 - MLB

Texas Rangers
6 :  2
Chicago Cubs
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 9, 2025 - MLB

Texas Rangers
6 :  2
Chicago Cubs

Apr 8, 2025 - MLB

Texas Rangers
6 :  10
Chicago Cubs

Apr 7, 2025 - MLB

Texas Rangers
0 :  7
Chicago Cubs

Apr 6, 2025 - MLB

San Diego Padres
8 :  7
Chicago Cubs

Apr 5, 2025 - MLB

San Diego Padres
1 :  7
Chicago Cubs

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Chicago Cubs
4 :  2
Los Angeles Dodgers

Apr 12, 2025 - MLB

Chicago Cubs
16 :  0
Los Angeles Dodgers

Apr 11, 2025 - MLB

Chicago Cubs
0 :  3
Los Angeles Dodgers

Apr 2, 2025 - MLB

Chicago Cubs
10 :  2
Athletics
San Diego Padres
San Diego Padres Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Colorado Rockies
0 :  6
San Diego Padres

Apr 12, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Apr 11, 2025 - MLB

Colorado Rockies
0 :  8
San Diego Padres

Apr 9, 2025 - MLB

San Diego Padres
2 :  1
Athletics
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 13, 2025 - MLB

Colorado Rockies
0 :  6
San Diego Padres

Apr 12, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Apr 11, 2025 - MLB

Colorado Rockies
0 :  8
San Diego Padres

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 9, 2025 - MLB

San Diego Padres
2 :  1
Athletics

Apr 8, 2025 - MLB

San Diego Padres
4 :  10
Athletics

Apr 7, 2025 - MLB

San Diego Padres
5 :  4
Athletics

Apr 6, 2025 - MLB

San Diego Padres
8 :  7
Chicago Cubs

Apr 5, 2025 - MLB

San Diego Padres
1 :  7
Chicago Cubs

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Chicago Cubs against San Diego Padres : Head to Head (H2H)

Chicago Cubs

50 %

San Diego Padres

50 %

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 6, 2025 - MLB

San Diego Padres
8 :  7
Chicago Cubs

Apr 5, 2025 - MLB

San Diego Padres
1 :  7
Chicago Cubs

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Mar 21, 2025 - MLB Spring Training

San Diego Padres
5 :  1
Chicago Cubs

Chicago Cubs - San Diego Padres Key Points

  1. The Cubs lead the all-time series vs. the Padres 287-241.
  2. The Padres won Game 1 of the series 10-4, but the Cubs lead the season series 3-2.
  3. Tuesday’s defeat was the first home loss for the Padres this season.
  4. 70% of moneyline tickets are on the Padres to win Game Three, but 74% of the handle is on Chicago.

Our Chicago Cubs vs San Diego Padres Prediction

The public is getting behind the OVER with 91% of the tickets and 85% of the handle. But we have two pitchers taking the mound with 1.59 ERAs. San Diego’s bullpen has a 1.46 ERA; Chicago's— 4.85. Yes, the Cubs have the most productive offense in baseball so far this season, but I just don’t see any reason to believe this game will be anything other than a tight, low-scoring game.

Our Cubs vs. Padres Pick: UNDER 7.5

Prediction:

 

UNDER 7.5

-105
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Chicago Cubs vs San Diego Padres Picks